Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production.
Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production.
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DOI：
10.1126/scitranslmed.abb6576
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发表时间：
2021-02-03
影响因子：
17.1
通讯作者：
Ju C
中科院分区：
文献类型：
--
作者：
Wang Y;Yang Y;Wang M;Wang S;Jeong JM;Xu L;Wen Y;Emontzpohl C;Atkins CL;Duong K;Moreno NF;Yuan X;Hall DR;Dar W;Feng D;Gao B;Xu Y;Czigany Z;Colgan SP;Bynon JS;Akira S;Brown JM;Eltzschig HK;Jacobsen EA;Ju C
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper cell immune responses. Unexpectedly, we identified a rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no eosinophils were detectable in healthy liver tissues before transplantation. Studies with two genetic mouse models of eosinophil deficiency and a mouse model of antibody-mediated eosinophil depletion revealed exacerbated liver injury after hepatic ischemia and reperfusion. Adoptive transfer of bone marrow–derived eosinophils normalized liver injury of eosinophil-deficient mice and reduced hepatic ischemia and reperfusion injury in wild-type mice. Mechanistic studies combining genetic and adoptive transfer approaches identified a critical role of suppression of tumorigenicity (ST2)–dependent production of interleukin-13 by eosinophils in the hepatoprotection against ischemia-reperfusion–induced injury. Together, these data provide insight into a mechanism of eosinophil-mediated liver protection that could serve as a therapeutic target to improve outcomes of patients undergoing liver transplantation.
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影响因子：
25.7
作者：
Liu, Yuanxing;Ji, Haofeng;Zhang, Yu;Shen, Xiuda;Gao, Feng;He, Xiangyi;Li, Gabriella A.;Busuttil, Ronald W.;Kuchroo, Vijay K.;Kupiec-Weglinski, Jerzy W.
通讯作者：
Kupiec-Weglinski, Jerzy W.
IL-33先于调节嗜酸性粒细胞承诺的IL-5之前，是嗜酸性粒细胞稳态所必需的。
DOI：
10.4049/jimmunol.1600611
发表时间：
2016-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Johnston LK;Hsu CL;Krier-Burris RA;Chhiba KD;Chien KB;McKenzie A;Berdnikovs S;Bryce PJ
通讯作者：
Bryce PJ
影响因子：
15.3
作者：
Jacobsen, Elizabeth A.;Ochkur, Sergei I.;Pero, Ralph S.;Taranova, Anna G.;Protheroe, Cheryl A.;Colbert, Dana C.;Lee, Nancy A.;Lee, James J.
通讯作者：
Lee, James J.
影响因子：
3.1
作者：
LIU, P;MCGUIRE, GM;JAESCHKE, H
通讯作者：
JAESCHKE, H
影响因子：
4.4
作者：
Kono, Hiroshi;Fujii, Hideki;Hara, Michio
通讯作者：
Hara, Michio