Virus-Inspired Deformable Mesoporous Nanocomposites for High Efficiency Drug Delivery
Virus-Inspired Deformable Mesoporous Nanocomposites for High Efficiency Drug Delivery
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病毒启发的可变形介孔纳米复合材料用于高效药物输送
DOI：
10.1002/smll.201906028
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发表时间：
2020-01-29
期刊：
影响因子：
13.3
通讯作者：
Qu, Junle
中科院分区：
文献类型：
--
作者：
Chen, Yu;Li, Xiaobin;Qu, Junle
介孔纳米颗粒作为一种多功能的癌症治疗平台已被广泛应用，但其细胞递送效率仍远未达到令人满意的水平。虽然可变形性正在成为影响细胞摄取增强的重要参数，但易于合成具有可调节力学性能的可变形介孔纳米复合材料具有挑战性，但对于更深入地了解细胞摄取机制和显着改善癌症治疗具有重要意义。本文采用有机硅烷辅助各向异性自组装方法，成功制备了具有可调力学性能的蛋黄壳结构偏心介孔有机硅（YEMO）纳米复合材料。论证了通过控制结构参数、介孔骨架交联度和反应旋转速率来精确控制YEMO力学性能的可行性。对该材料的制备机理和力学性能进行了详细的研究。YEMO的杨氏模量（E-Y）可在2.4 ~ 65 MPa范围内调节。因此，在相同的孵育时间下，实现了细胞摄取从约15%到约80%的连续控制。为了进一步证明具有柔软特性的YEMO具有更高的给药效率，我们证明了装载抗癌药物阿霉素的“软”YEMO比“硬”的YEMO具有更高的毒性。
Mesoporous nanoparticles as a versatile platform for cancer theranostics have been widely used, but their cellular delivery efficiency is still far from satisfactory. Although deformability is emerging as an important parameter influencing cellular uptake enhancement, the facile synthesis of deformable mesoporous nanocomposite with adjustable mechanical property is challenging but meaningful for a deeper understanding of cellular uptake mechanisms and significantly improving cancer therapy. In this work, yolk-shell structured eccentric mesoporous organosilica (YEMO) nanocomposites with adjustable mechanical property are successfully prepared by an organosilane-assisted anisotropic self-assembly approach. The feasibility to precisely control the mechanical property of the YEMO by manipulating the structural parameters, the crosslinking degree of mesoporous framework, and the rotation rate of the reaction is demonstrated. The study of the fabrication mechanism and mechanical properties of YEMO are discussed in detail. The Young's modulus (E-Y) of YEMO can be adjusted from 2.4 to 65 MPa. Thereby, the continuous control of the cellular uptake from approximate to 15% to approximate to 80% under the same incubation time is achieved. To further prove the higher efficiency drug delivery of YEMO with soft characteristics, the higher toxicity of the "soft" YEMO loaded with the anticancer drug doxorubicin compared to the "stiff" one is demonstrated.