Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
复制标题
在体外，大鼠小胶质细胞在阿尔茨海默病斑块上表现出密度增加。
DOI：
10.1006/exnr.1997.6678
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Crutcher,KA
中科院分区：
文献类型：
--
作者：
Joshi,SN;Crutcher,KA
The relationship of microglia to senile plaques was investigated by culturing glial cells derived from neonatal rat brain on cryostat sections of Alzheimer's disease (AD) or control brain. Rat microglia were identified by their uptake of DiI-acetylated LDL. Plaques were colocalized using Thioflavin-S staining. Although the number of microglia attached to AD tissue sections did not differ significantly from the number on control brain tissue, the density of microglia on senile plaques was significantly greater than on nonsenile plaque areas of the same sections. These results suggest that microglia may have a higher affinity for senile plaques than for nonsenile plaque regions of AD brain tissue and are consistent with the hypothesis that microglia respond to plaques.
