The influence of hypoxic physical activity on cfDNA as a new marker of vascular inflammation.
The influence of hypoxic physical activity on cfDNA as a new marker of vascular inflammation.
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DOI：
10.5114/aoms.2015.56341
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发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Banach M
中科院分区：
文献类型：
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作者：
Pokrywka A;Zembron-Lacny A;Baldy-Chudzik K;Orysiak J;Sitkowski D;Banach M
循环无细胞DNA（cfDNA）的现象对于许多生物医学学科（包括运动生物化学和生理学领域）是重要的。cfDNA可能通过内皮细胞和循环内皮祖细胞（EPC）的凋亡和/或通过剧烈运动诱导的免疫细胞的NETosis释放到血浆中。cfDNA的增加被描述为过度训练综合征的潜在标志，并且可能与运动员的无菌性血管炎症有关。然而，全身炎症和cfDNA与运动员内皮功能障碍的相关性仍不清楚。在这篇综述文章中，我们提供了运动诱导的cfDNA释放到循环中的最新概述，特别强调其与细胞凋亡和NETosis的关系以及低氧体力活动对运动员血管炎症的影响。
The phenomenon of circulating cell-free DNA (cfDNA) is important for many biomedical disciplines including the field of exercise biochemistry and physiology. It is likely that cfDNA is released into the plasma by apoptosis of endothelial cells and circulating endothelial progenitor cells (EPCs), and/or by NETosis of immune cells induced by strenuous exercise. Increases of cfDNA are described to be a potential hallmark for the overtraining syndrome, and might be related to aseptic vascular inflammation in athletes. Yet, the relevance of systemic inflammation and cfDNA with endothelial dysfunction in athletes still remains unclear. In this review article, we provide a current overview of exercise-induced cfDNA release to the circulation with special emphasis on its relationship with apoptosis and NETosis and the effect of hypoxic physical activity on vascular inflammation in athletes.