The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature.
The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature.
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DOI：
10.1016/j.mad.2018.04.002
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发表时间：
2019-01
影响因子：
5.3
通讯作者：
De Luca M
中科院分区：
文献类型：
--
作者：
De Luca M
细胞外基质（ECM）是一个复杂的网络，为细胞提供结构和锚定支持，以稳定细胞形态和组织结构。ECM还通过其与细胞之间持续的双向相互作用，控制着细胞动态行为和命运的许多方面。细胞与周围ECM成分之间的相互作用涉及多个生物过程，包括发育和成年组织损伤修复，贯穿多个物种的整个生命周期。本文综述了越来越多的证据表明细胞-基质相互作用在衰老过程中起着关键作用。本文第一部分的重点是最近使用细胞来源的去细胞化ECM的研究，这些研究强烈表明，ECM中与年龄相关的变化会诱导细胞衰老，这是衰老的一个公认的标志。随后对遗传学研究结果进行了回顾，表明参与细胞- ecm粘附和基质介导的细胞内信号级联反应的基因变化会影响寿命。最后，提到了新的数据提出了细胞-基质相互作用和肾素-血管紧张素系统之间复杂的相互作用，这可能对哺乳动物动脉硬度随着年龄的增长产生重大影响。
The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell’s dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These interactions between the cell and components of the surrounding ECM are implicated in several biological processes, including development and adult tissue repair in response to injury, throughout the lifespan of multiple species. The present review gives an overview of the growing evidence that cell-matrix interactions play a pivotal role in the aging process. The focus of the first part of the article is on recent studies using cell-derived decellularized ECM, which strongly suggest that age-related changes in the ECM induce cellular senescence, a well-recognized hallmark of aging. This is followed by a review of findings from genetic studies indicating that changes in genes involved in cell–ECM adhesion and matrix-mediated intracellular signaling cascades affect longevity. Finally, mention is made of novel data proposing an intricate interplay between cell-matrix interactions and the renin-angiotensin system that may have a significant impact on mammalian arterial stiffness with age.
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影响因子：
4
作者：
Bing, Hai-Tao;Wang, Chen-Guang;Wang, Kui
通讯作者：
Wang, Kui
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
--
作者：
Basso, N;Paglia, N;Inserra, F
通讯作者：
Inserra, F
影响因子：
4.3
作者：
Cox TR;Erler JT
通讯作者：
Erler JT
影响因子：
18.2
作者：
Campisi J
通讯作者：
Campisi J