Serum concentrations of gabapentin in cats with chronic kidney disease.
Serum concentrations of gabapentin in cats with chronic kidney disease.
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DOI：
10.1177/1098612x221077017
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发表时间：
2022-12
影响因子：
1.7
通讯作者：
van Haaften, Karen A.
中科院分区：
文献类型：
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作者：
Quimby, Jessica M.;Lorbach, Sarah K.;Saffire, Ashlie;Kennedy, Amanda;Wittenburg, Luke A.;Aarnes, Turi K.;Creighton, Karina J.;Jones, Sarah E.;Paschall, Rene E.;King, Emily M.;Bruner, Clara E.;Wallinger, Jessica N.;van Haaften, Karen A.
本研究的目的是评估患有慢性肾病 (CKD) 的猫与临床健康猫的加巴喷丁血清浓度。五只健康的猫参加了药代动力学研究。口服单次20mg/kg剂量的加巴喷丁，并在0、0.25、0.5、1、1.5、2、3、4、8、12、24和36小时通过颈静脉导管采集血液。使用液相色谱法和串联质谱法测量血清加巴喷丁浓度。进行非房室药代动力学分析。同样的 5 只健康猫加上 25 只患有稳定国际肾脏兴趣协会 2 期 (n = 14) 和 3 只 (n = 11) CKD 的猫参加了一项有限抽样研究。两组猫均接受单次10mg/kg剂量的加巴喷丁，并在给药后3小时和8小时获得血清加巴喷丁浓度和依从性评分。患有 CKD 的猫在 3 小时（P = 0.0012 CKD 与正常 10 mg/kg 相比；P = 0.008 CKD 与正常 20 mg/kg）和 8 小时（P <0.0001 CKD 与正常）时的剂量归一化血清加巴喷丁浓度显着高于正常猫10 mg/kg；P <0.0001 CKD 与正常 20 mg/kg 相比）。 3小时和8小时剂量标准化血清加巴喷丁浓度均与血清肌酐（3小时：P = 0.03，r = 0.39；8小时：P = 0.001，r = 0.57）和对称二甲基精氨酸（3小时：P = 0.57）显着相关。 P = 0.03，r = 0.41；8小时：P = 0.007，r = 0.48）。 3小时血清加巴喷丁浓度与依从性评分之间存在显着相关性（P = 0.0002，r = 0.68）。接受 10 mg/kg 加巴喷丁治疗的 CKD 猫的剂量标准化血清浓度显着高于接受 20 mg/kg 加巴喷丁治疗的正常猫，这支持了该患者群体中减少剂量的需要。
The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24 and 36 h via a jugular catheter. Serum gabapentin concentrations were measured using liquid chromatography coupled to tandem mass spectrometry. Non-compartmental pharmacokinetic analysis was performed. The same five healthy cats plus 25 cats with stable International Renal Interest Society stage 2 (n = 14) and 3 (n = 11) CKD were enrolled in a limited sampling study. Cats in both groups received a single 10 mg/kg dose of gabapentin, and serum gabapentin concentrations and compliance scores were obtained 3 and 8 h post-administration. Cats with CKD had significantly higher dose-normalized serum gabapentin concentrations than normal cats at 3 h (P = 0.0012 CKD vs normal 10 mg/kg; P = 0.008 CKD vs normal 20 mg/kg) and 8 h (P <0.0001 CKD vs normal 10 mg/kg; P <0.0001 CKD vs normal 20 mg/kg). Both 3 and 8 h dose-normalized serum gabapentin concentrations were significantly correlated with serum creatinine (3 h: P = 0.03, r = 0.39; 8 h: P = 0.001, r = 0.57) and symmetric dimethylarginine (3 h: P = 0.03, r = 0.41; 8 h: P = 0.007, r = 0.48). There was a significant correlation between 3 h serum gabapentin concentrations and compliance scores (P = 0.0002, r = 0.68). Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population.
DOI：
10.1208/s12248-016-0022-z
发表时间：
2017-03
期刊：
The AAPS journal
影响因子：
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作者：
通讯作者：
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