Right Isomerism of the Brain in Inversus Viscerum Mutant Mice
Right Isomerism of the Brain in Inversus Viscerum Mutant Mice
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DOI：
10.1371/journal.pone.0001945
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发表时间：
2008-04-16
期刊：
影响因子：
3.7
通讯作者：
Ito, Isao
中科院分区：
文献类型：
--
作者：
Kawakami, Ryosuke;Dobi, Alice;Ito, Isao
左右（L-R）不对称性是高阶神经功能的一个基本特征。然而，大脑不对称的分子基础仍然不清楚。我们最近报道了N-甲基-D-天冬氨酸受体（NMDAR）亚单位GluR β 2（NR 2B）在海马突触中的不同分布引起的海马回路L-R不对称性。利用电生理学和免疫细胞化学方法，我们分析了内脏器官随机偏侧化的内脏反转（iv）小鼠的海马回路。iv小鼠海马缺乏L-R不对称性，它表现出右异构的突触分布的α 2亚基，无论内脏器官的偏侧性。海马体的这种独立的右异构体是第一个证据，表明iv突变下游的一种独特机制导致了大脑的不对称性。
Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-D-aspartate receptor (NMDAR) subunit GluR epsilon 2 (NR2B) in hippocampal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the epsilon 2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry.