Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes.
Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes.
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DOI：
10.3389/fimmu.2017.00186
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发表时间：
2017
影响因子：
7.3
通讯作者：
Nakao S
中科院分区：
文献类型：
--
作者：
Espinoza JL;Kotecha R;Nakao S
获得性骨髓衰竭综合征包括一组独特的疾病，其特征是骨髓(BM)有效产生成熟细胞的减少。在大多数情况下，这些综合征是在分化的不同阶段，免疫介导的造血干细胞或其祖细胞被破坏的结果。微生物感染也与造血干细胞损伤有关，并可能导致相关的一过性或永久性骨髓衰竭，最近的证据强调了共生微生物及其代谢产物对造血的潜在影响。我们总结了微生物和宿主免疫系统之间的相互作用，并强调它们如何影响获得性骨髓衰竭的发展。
Acquired bone marrow failure syndromes encompass a unique set of disorders characterized by a reduction in the effective production of mature cells by the bone marrow (BM). In the majority of cases, these syndromes are the result of the immune-mediated destruction of hematopoietic stem cells or their progenitors at various stages of differentiation. Microbial infection has also been associated with hematopoietic stem cell injury and may lead to associated transient or persistent BM failure, and recent evidence has highlighted the potential impact of commensal microbes and their metabolites on hematopoiesis. We summarize the interactions between microorganisms and the host immune system and emphasize how they may impact the development of acquired BM failure.