Saying NO to H2S: A Story of HNO, HSNO, and SSNO-
Saying NO to H2S: A Story of HNO, HSNO, and SSNO-
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DOI：
10.1021/acs.inorgchem.8b02592
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发表时间：
2019-04-01
影响因子：
4.6
通讯作者：
Filipovic, Milos R.
中科院分区：
文献类型：
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作者：
Ivanovic-Burmazovic, Ivana;Filipovic, Milos R.
无机小分子之间的相互作用对于理解基本的反应机制和一些在有机分子之前并导致生命起源的化学进化的初始过程是基本的。这些过程的动力学适用于各种新化学实体的快速生成和一系列化学反应的传播，这一特性即使在生物系统中也是理想的信号目的。NO和H_2S是目前公认的生物气体递质，通过蛋白质修饰参与调节生理功能，如S-亚硫醇、二硫化物和过硫化物的形成。在这一观点下，我们综述了目前对NO(以及有机和金属亚硝基)与H_2S在化学和生化环境中相互作用的理解。通过HNO、(H)SNO(及其异构体)、(H)SSNO和多硫化物的形成，这两种气体递质启动了在细胞信号转导中起重要作用的反应网络。这些氮和硫物种的化学反应和生物学效应仍未解决，因此，所有这些物种之间的相互作用代表着一个具有挑战性的跨学科领域，等待着令人兴奋的新发现。我们解决了一些有趣的和开放的问题，并为未来的研究方向提供了观点。
Interactions between small inorganic molecules are fundamental to the understanding of basic reaction mechanisms and some of the initial processes of chemical evolution that preceded organic molecules and led to the origin of life. The kinetics of these processes are suitable for the fast generation of a variety of new chemical entities and the propagation of a cascade of chemical reactions, a property that is ideal for signaling purposes even in biological systems. NO and H2S are such molecules that are nowadays recognized as biological gasotransmitters involved in the regulation of physiological functions through protein modifications such as S-nitrosothiol, disulfide, and persulfide formations. In this Viewpoint, we review the current understanding of interactions of NO (and organic and metal nitrosyl species) with H2S, in both chemical and biochemical contexts. Through the formation of HNO, (H)SNO (and its isomers), (H)SSNO, and polysulfides, these two gasotransmitters initiate reaction networks with significant roles in cell signaling. The chemical reactivities and biological effects of these nitrogen and sulfur species are still unresolved, and, thus, a cross-talk between all of them represents a challenging interdisciplinary field that awaits exciting new findings. We tackle some of the intriguing and open questions and provide perspectives for future research directions.