Role of PD-L1 in Gut Mucosa Tolerance and Chronic Inflammation.
Role of PD-L1 in Gut Mucosa Tolerance and Chronic Inflammation.
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PD-L1在肠道粘膜耐受和慢性炎症中的作用
DOI：
10.3390/ijms21239165
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发表时间：
2020-12-01
影响因子：
5.6
通讯作者：
Pinchuk IV
中科院分区：
文献类型：
--
作者：
Chulkina M;Beswick EJ;Pinchuk IV
胃肠道(GI)粘膜是体内最复杂的系统之一。它有一个多样化的共生微生物群，不断受到食物和微生物成分的挑战，同时提供必要的营养物质和抵御病原体。出于这些原因，调节细胞和受体很可能在维持肠道粘膜稳态方面发挥核心作用。最近的癌症免疫治疗经验表明，B7负性共刺激因子PD-L1在粘膜动态平衡中起着关键作用。在这篇综述中，我们总结了目前支持PD-L1在胃肠道粘膜耐受中的关键作用的知识，以及它的表达和信号异常如何促进肠道炎症和癌症。在胃肠道病理中观察到PD-L1和/或PD-1/PD-L1信号通路的异常表达。我们还讨论了目前我们的知识差距，关于PD-L1信号在胃肠道内的稳态和病理学。最后，我们总结了目前对该途径如何被靶向开发新的治疗方法的理解。
The gastrointestinal (GI) mucosa is among the most complex systems in the body. It has a diverse commensal microbiome challenged continuously by food and microbial components while delivering essential nutrients and defending against pathogens. For these reasons, regulatory cells and receptors are likely to play a central role in maintaining the gut mucosal homeostasis. Recent lessons from cancer immunotherapy point out the critical role of the B7 negative co-stimulator PD-L1 in mucosal homeostasis. In this review, we summarize the current knowledge supporting the critical role of PD-L1 in gastrointestinal mucosal tolerance and how abnormalities in its expression and signaling contribute to gut inflammation and cancers. Abnormal expression of PD-L1 and/or the PD-1/PD-L1 signaling pathways have been observed in the pathology of the GI tract. We also discuss the current gap in our knowledge with regards to PD-L1 signaling in the GI tract under homeostasis and pathology. Finally, we summarize the current understanding of how this pathway is currently targeted to develop novel therapeutic approaches.
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免疫调节配体的B7家族。
影响因子：
12.3
作者：
Collins, Mary;Ling, Vincent;Carreno, Beatriz M
通讯作者：
Carreno, Beatriz M
DOI：
10.4049/jimmunol.1203441
发表时间：
2014-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beswick EJ;Johnson JR;Saada JI;Humen M;House J;Dann S;Qiu S;Brasier AR;Powell DW;Reyes VE;Pinchuk IV
通讯作者：
Pinchuk IV
影响因子：
7.3
作者：
Beswick EJ;Grim C;Singh A;Aguirre JE;Tafoya M;Qiu S;Rogler G;McKee R;Samedi V;Ma TY;Reyes VE;Powell DW;Pinchuk IV
通讯作者：
Pinchuk IV
影响因子：
4.4
作者：
Bulut, Esin Alpdundar;Kocabas, Banu Bayyurt;Gursel, Mayda
通讯作者：
Gursel, Mayda
影响因子：
3.1
作者：
Beswick, Ellen J.;Pinchuk, Irina V.;Reyes, Victor E.
通讯作者：
Reyes, Victor E.