Abnormal renal hemodynamics and pressure-natriuresis relationship in Dahl salt-sensitive rats.
Abnormal renal hemodynamics and pressure-natriuresis relationship in Dahl salt-sensitive rats.
复制标题
DOI：
10.1152/ajprenal.1986.251.1.f57
复制
发表时间：
1986-07
期刊：
影响因子：
--
通讯作者：
R. Roman
中科院分区：
文献类型：
--
作者：
R. Roman
我们比较了达尔盐抵抗(R)大鼠、高血压前期和高血压达尔盐敏感(S)大鼠肾脏对肾灌注压（RPP）变化的反应，以确定压力利尿反应的异常是否参与了这种形式的高血压的发展。S和R大鼠肾脏的神经和内分泌背景可能存在差异，通过去神经切断肾脏，并通过静脉滴注固定血浆中抗利尿激素、醛固酮、皮质酮和去甲肾上腺素的水平来消除。R大鼠平均动脉压为124 +/- 1mmhg，高血压前期S大鼠平均动脉压为133 +/- 1mmhg，高血压S大鼠平均动脉压为158 +/- 2mmhg。三组对照肾血流量（RBF）和肾小球滤过率（GFR）无显著差异。正常血压S和R大鼠的RBF在80 ~ 160 mmHg的压力范围内自动调节。当压力大于100 mmHg时，R大鼠和大于120 mmHg时，高血压前期S大鼠GFR自动调节。相比之下，高血压达尔S大鼠的RBF只有在压力大于110 mmHg时才会自动调节，而当RPP低于150 mmHg时，GFR明显低于对照组。在R大鼠中，将RPP从100 mmHg增加到150 mmHg会使尿流量和钠排泄增加5倍。在高血压前期或高血压Dahl S大鼠中，尿流量、钠排泄和RPP之间关系的斜率小于R大鼠的一半。（摘要删节250字）
The renal responses to changes in renal perfusion pressure (RPP) were compared in Dahl salt-resistant (R) rats and in prehypertensive and hypertensive Dahl salt-sensitive (S) rats to determine whether an abnormality in the pressure diuresis response is involved in the development of this form of hypertension. Possible differences in the neural and endocrine background to the kidney of S and R rats were eliminated by denervating the kidney and by holding plasma levels of vasopressin, aldosterone, corticosterone, and norepinephrine fixed by intravenous infusion. Arterial pressure averaged 124 +/- 1 mmHg in R rats, 133 +/- 1 mmHg in prehypertensive S rats, and 158 +/- 2 mmHg in hypertensive S rats. Control renal blood flows (RBF) and glomerular filtration rates (GFR) were not significantly different in the three groups. RBF was autoregulated over a range of pressures from 80 to 160 mmHg in normotensive S and R rats. GFR was autoregulated at pressures greater than 100 mmHg in R rats and greater than 120 mmHg in prehypertensive S rats. In contrast, RBF was only autoregulated at pressures greater than 110 mmHg in hypertensive Dahl S rats, and GFR was significantly reduced from control when RPP was lowered below 150 mmHg. In R rats, increasing RPP from 100 to 150 mmHg produced a fivefold increase in urine flow and sodium excretion. In prehypertensive or hypertensive Dahl S rats the slopes of the relationships between urine flow, sodium excretion, and RPP were less than half of those seen in R rats.(ABSTRACT TRUNCATED AT 250 WORDS)