Trichostatin C. A new inducer of differentiation of friend leukemic cells.
Trichostatin C. A new inducer of differentiation of friend leukemic cells.
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Trichostatin C。一种新的白血病细胞分化诱导剂。
DOI：
10.1271/bbb1961.49.563
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
T. Beppu
中科院分区：
文献类型：
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作者：
Minoru Yoshida;Y. Iwamoto;T. Uozumi;T. Beppu
Friend等人建立的鼠红白血病细胞1)是转化细胞，在红细胞生成的相对晚期阶段似乎在分化方面受到阻碍。2)通过在培养基中添加各种化学物质，例如二甲基亚砜3)和六亚甲基(HMBA)，可以在体外诱导这些细胞表达正常红细胞生成的各种细胞功能。多年来，该细胞系已被认为是一个有用的模型系统，用于研究如何在单细胞谱系内以协调方式调节特化分化细胞的功能特征。 Friend白血病诱导分化
Murine erythroleukemia cells established by Friend et al.l) are transformed cells that ap-pear to be blocked in differentiation at a relatively late stage in erythropoesis.2) These cells can be induced in vitro to express various cellular functions of normal erythropoesis by adding various chemicals such as dimethylsul-foxide3) and hexamethylene (HMBA) to the culture medium. This line has been recognized for many years as a useful model system for investigating how functions characteristic of a specialized differentiated cell are regulated in a coordinate mannerwithin a single cell lineage. inducing differentiation of Friend leukemic