Synthetic human pancreas growth hormone-releasing factor (hpGRF1-44-NH2) stimulates growth hormone secretion in normal men.
Synthetic human pancreas growth hormone-releasing factor (hpGRF1-44-NH2) stimulates growth hormone secretion in normal men.
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合成人胰腺生长激素释放因子 (hpGRF1-44-NH2) 可刺激正常男性的生长激素分泌。
DOI：
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发表时间：
1983
影响因子：
5.8
通讯作者：
M. Grumbach
中科院分区：
文献类型：
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作者：
S. Rosenthal;E. Schriock;S. Kaplan;R. Guillemin;M. Grumbach
将人胰腺生长因子释放因子hpGRF 1 -44-NH 2（hpGRF 44）（一种44个氨基酸的酰胺化肽）的合成复制品给予7名正常男性。除了安慰剂之外，4名受试者接受3剂hpGRF 44（0.5微克/kg、5微克/kg、10微克/kg），而1名受试者接受2剂（5微克/kg、10微克/kg），2名受试者接受1剂（0.5微克/kg或5微克/kg），各自作为快速静脉内注射。与安慰剂相比，在每个剂量下观察到循环生长激素（GH）显著增加（0.5 μ g/kg，p = 0.05; 5 μ g/kg，p小于0.005; 10 μ g/kg，p = 0.01），最大反应相当。在研究的所有剂量下，血浆GH在5分钟内升高，大多数患者在30-45分钟时达到峰值反应。其他任何垂体前叶激素或胰岛素均无相关变化。除了短暂的潮红和生命体征的微小变化外，未观察到副作用。这些研究的结果支持hpGRF 44用于评估GH分泌和储备的潜在有用性，以及该肽或类似物作为刺激GH释放的治疗剂的潜在有用性。
A synthetic replicate of human pancreas growth hormone-releasing factor, hpGRF1-44-NH2, (hpGRF44), a 44-amino acid amidated peptide, was administered to seven normal men. In addition to placebo, 4 subjects received 3 doses of hpGRF44 (0.5 microgram/kg, 5 micrograms/kg, 10 micrograms/kg), while one subject received 2 doses (5 micrograms/kg, 10 micrograms/kg) and 2 subjects received one dose (0.5 microgram/kg or 5 micrograms/kg), each as a rapid intravenous injection. A significant increase in circulating growth hormone (GH) was observed at each dose (0.5 microgram/kg, p = 0.05; 5 micrograms/kg, p less than 0.005; 10 micrograms/kg, p = 0.01) when compared to placebo, with equivalent maximal responses. At all doses studied a rise in plasma GH occurred within 5 min, with a peak response in most patients at 30-45 min. There were no associated changes in any of the other anterior pituitary hormones or insulin. Other than transient flushing and minimal changes in vital signs, no side effects were noted. The results of these studies support the potential usefulness of hpGRF44 for the assessment of GH secretion and reserve, and of this peptide or an analog as a therapeutic agent to stimulate GH release.