EFFICACY AND SAFETY OF QUINIDINE THERAPY FOR MAINTENANCE OF SINUS RHYTHM AFTER CARDIOVERSION - A METAANALYSIS OF RANDOMIZED CONTROL TRIALS
EFFICACY AND SAFETY OF QUINIDINE THERAPY FOR MAINTENANCE OF SINUS RHYTHM AFTER CARDIOVERSION - A METAANALYSIS OF RANDOMIZED CONTROL TRIALS
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DOI：
10.1161/01.cir.82.4.1106
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发表时间：
1990-10-01
期刊：
影响因子：
37.8
通讯作者：
CHALMERS, TC
中科院分区：
文献类型：
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作者：
COPLEN, SE;ANTMAN, EM;CHALMERS, TC
由于评估奎尼丁在慢性房颤复律后维持窦性心律中的作用的个别研究涉及的患者相对较少，因此进行了随机对照试验的荟萃分析。1970年至1984年间发表的6项试验是由两位盲评人根据研究设计和统计分析挑选出来的。这六项试验的数据涉及808名患者，在对试验中治疗效果的同质性进行测试后，将这些数据汇集在一起。对奎尼丁组和对照组在复律后3、6和12个月仍保持窦性心律的患者的百分比进行了生命表估计。奎尼丁组在复律后3、6和12个月仍保持窦性心律的患者比例分别为69%、58%和50%。在相同的时间间隔，对照组患者保持窦性心律的比例分别为45%、33%和25%。奎尼丁组和对照组在3、6和12个月的合并率或窦性心律患者比例的差值分别为24%、23%和24%(P
Because individual studies evaluating the role of quinidine in the maintenance of sinus rhythm after cardioversion from chronic atrial fibrillation have involved relatively few patients, a meta-analysis of randomized control trials was performed. Six trials published between 1970 and 1984 were selected by two blinded reviewers based on study design and statistical analysis. Data from these six trials involving 808 patients were pooled after testing for homogeneity of treatment effects across trials. Life table estimates of the percent of patients still in sinus rhythm at 3, 6, and 12 months after cardioversion were constructed for quinidine and control groups. The proportion of patients remaining in sinus rhythm in the quinidine group was 69%, 58%, and 50% at 3, 6, and 12 months postcardioversion respectively. The proportion of patients remaining in sinus rhythm in the control group was 45%, 33%, and 25% at the same time intervals. The pooled rate difference, or difference in proportion of patients in sinus rhythm between quinidine and control groups, was 24%, 23% and 24% at 3, 6, and 12 months of follow-up (p