A multicompartment model of carboxyhemoglobin and carboxymyoglobin responses to inhalation of carbon monoxide
A multicompartment model of carboxyhemoglobin and carboxymyoglobin responses to inhalation of carbon monoxide
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DOI：
10.1152/japplphysiol.00217.2003
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发表时间：
2003-09-01
影响因子：
3.3
通讯作者：
Bruce, MC
中科院分区：
文献类型：
--
作者：
Bruce, EN;Bruce, MC
我们已经开发了一个模型，预测一氧化碳（CO）在体内的分布导致急性吸入暴露于CO。该模型包括肺室，动脉和静脉血室，肌肉和非肌肉软组织与血管和非血管亚室。在该模型中，允许CO在组织的血管和非血管亚室之间扩散，并在肌肉组织的非血管亚室中与肌红蛋白联合收割机结合。氧合血红蛋白解离曲线由修改的Hill方程表示，其参数是碳氧血红蛋白（HbCO）水平的函数。根据个体受试者的年龄、体重和身高，根据预测公式计算骨骼肌质量和心输出量值。我们证明，该模型适合从CO再呼吸研究的数据时，CO扩散到肌肉室被认为是。该模型还拟合了HbCO对单次或多次暴露于CO的反应，每次持续几分钟。此外，该模型再现了动脉和静脉HbCO水平之间的差异，并复制从Coburn-Forster-Kane方程的CO暴露的1至83小时的持续时间的预测。与基于Coburn-Forster-Kane方程的方法相反，本模型预测在吸入恒定或可变水平的CO期间，CO在血管和组织隔室中的吸收和分布。
We have developed a model that predicts the distribution of carbon monoxide ( CO) in the body resulting from acute inhalation exposures to CO. The model includes a lung compartment, arterial and venous blood compartments, and muscle and nonmuscle soft tissues with both vascular and nonvascular subcompartments. In the model, CO is allowed to diffuse between the vascular and nonvascular subcompartments of the tissues and to combine with myoglobin in the nonvascular subcompartment of muscle tissue. The oxyhemoglobin dissociation curve is represented by a modified Hill equation whose parameters are functions of the carboxyhemoglobin (HbCO) level. Values for skeletal muscle mass and cardiac output are calculated from prediction formulas based on age, weight, and height of individual subjects. We demonstrate that the model fits data from CO rebreathing studies when diffusion of CO into the muscle compartment is considered. The model also fits responses of HbCO to single or multiple exposures to CO lasting for a few minutes each. In addition, the model reproduces reported differences between arterial and venous HbCO levels and replicates predictions from the Coburn-Forster-Kane equation for CO exposures of a 1- to 83-h duration. In contrast to approaches based on the Coburn-Forster-Kane equation, the present model predicts uptake and distribution of CO in both vascular and tissue compartments during inhalation of either constant or variable levels of CO.