COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
复制标题
切除的胰头腺癌中 COX-2 过表达与良好的预后相关
作者：
Ewa Pomianowska;A. Schjølberg;O. Clausen;I. Gladhaug
环氧合酶-2(COX-2)的过度表达与胰头腺癌的发生和发展密切相关。关于COX在这些肿瘤中的预后重要性的数据是不一致的，也是相互矛盾的。方法连续2 30例胰腺癌(PC，n = 92例)、壶腹癌(AC，n = 62例)和远端胆管癌(DBC，n = 76例)行胰腺十二指肠切除术。免疫组织化学方法检测环氧合酶-2的表达。分析COX-2表达与分化程度、分化类型(胰胆系与肠系)和淋巴结比(LNR)等组织病理学变量的关系。结果COX-2在PC、AC和DBC中的阳性表达分别为71%、77%和72%。不考虑肿瘤来源，COX-2阳性肿瘤患者的总体生存率比COX-2阴性患者更有利(PC组p = 0.043，AC组p = 0.011，DBC组p = 0.06)。在组织病理学分化的胰胆型肿瘤中，COX-2的表达并不显著影响患者的总体生存。在有肠道分化的AC中，COX-2的表达显著预示着患者的良好生存(p = 0.003)。在PC中，COX-2的表达与高分化程度显著相关(p = 0.002)。结论COX-2在胰腺癌、壶腹癌和胆管远端癌组织中均有高表达，COX-2在上述三种肿瘤中均有生存优势。在胰腺癌中，COX-2的过度表达与分化程度显著相关，并独立预测预后良好。
BackgroundOverexpression of cyclooxygenase-2 (COX-2) has been implicated in oncogenesis and progression of adenocarcinomas of the pancreatic head. The data on the prognostic importance of COX expression in these tumours is inconsistent and conflicting. We evaluated how COX-2 overexpression affected overall postoperative survival in pancreatic head adenocarcinomas.MethodsThe study included 230 consecutive pancreatoduodenectomies for pancreatic cancer (PC, n = 92), ampullary cancer (AC, n = 62) and distal bile duct cancer (DBC, n = 76). COX-2 expression was assessed by immunohistochemistry. Associations between COX-2 expression and histopathologic variables including degree of differentiation, histopathologic type of differentiation (pancreatobiliary vs. intestinal) and lymph node ratio (LNR) were evaluated. Unadjusted and adjusted survival analysis was performed.ResultsCOX-2 staining was positive in 71% of PC, 77% in AC and 72% in DBC. Irrespective of tumour origin, overall patient survival was more favourable in patients with COX-2 positive tumours than COX-2 negative (p = 0.043 in PC, p = 0.011 in AC, p = 0.06 in DBC). In tumours of pancreatobiliary type of histopathological differentiation, COX-2 expression did not significantly affect overall patient survival. In AC with intestinal differentiation COX-2 expression significantly predicted favourable survival (p = 0.003). In PC, COX-2 expression was significantly associated with high degree of differentiation (p = 0.002). COX-2 and LNR independently predicted good prognosis in a multivariate model.ConclusionsCOX-2 is overexpressed in pancreatic cancer, ampullary cancer and distal bile duct cancer and confers a survival benefit in all three cancer types. In pancreatic cancer, COX-2 overexpression is significantly associated with the degree of differentiation and independently predicts a favourable prognosis.
影响因子：
11.2
作者：
H. Sano;Y. Kawahito;R. Wilder;A. Hashiramoto;S. Mukai;K. Asai;S. Kimura;H. Kato;M. Kondo;T. Hla
通讯作者：
H. Sano;Y. Kawahito;R. Wilder;A. Hashiramoto;S. Mukai;K. Asai;S. Kimura;H. Kato;M. Kondo;T. Hla
影响因子：
4.8
作者：
Colby, Jennifer K.;Klein, Russell D.;Fischer, Susan M.
通讯作者：
Fischer, Susan M.