Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936.
Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936.
复制标题
DOI：
10.1016/j.neurobiolaging.2016.03.011
复制
发表时间：
2016-06
影响因子：
4.2
通讯作者：
Wardlaw JM
中科院分区：
文献类型：
--
作者：
Dickie DA;Ritchie SJ;Cox SR;Sakka E;Royle NA;Aribisala BS;Valdés Hernández Mdel C;Maniega SM;Pattie A;Corley J;Starr JM;Bastin ME;Deary IJ;Wardlaw JM
我们的目的是确定1973年多个血管危险因素（VRF）与1973年至1976年白色高信号（WMH）进展之间的关系。我们计算了相关性和广义估计方程模型的综合范围内的VRF在73年和变化WMH量从73年到76年。在简单相关模型中，73岁时较高的收缩压（rho = 0.126，p = 0.009）和舒张压（rho = 0.120，p = 0.013）是76岁时较大WMH体积的显著预测因素。然而，在一个完全校正的模型中，73岁时测量的血压和自我报告的高血压都不是WMH体积变化的显著预测因子，该模型解释了73岁时的初始WMH体积。较低的高密度脂蛋白胆固醇（β =-0.15%颅内，-1.80 mL; p < 0.05）和当前吸烟（β = 0.43%颅内，5.49 mL; p < 0.05）是WMH体积从73岁到76岁变化的唯一显著VRF预测因子。关注戒烟和降脂，而不仅仅是抗高血压药物，可能会导致生命第八个十年WMH增长的减少。
We aimed to determine associations between multiple vascular risk factors (VRF) at ∼73 years and progression of white matter hyperintensities (WMH) from ∼73 years to ∼76 years. We calculated correlations and generalized estimating equation models of a comprehensive range of VRF at 73 years and change in WMH volume from 73 years to 76 years. Higher systolic (rho = 0.126, p = 0.009) and diastolic (rho = 0.120, p = 0.013) blood pressure at 73 years were significant predictors for greater WMH volume at 76 years in a simple correlation model. However, neither measured blood pressure nor self-reported hypertension at 73 years was significant predictors of WMH volume change in a fully adjusted model which accounted for initial WMH volume at 73 years. Lower high-density lipoprotein cholesterol (beta = −0.15 % intracranial, −1.80 mL; p < 0.05) and current smoking (beta = 0.43 % intracranial, 5.49 mL; p < 0.05) were the only significant VRF predictors of WMH volume change from 73 years to 76 years. A focus on smoking cessation and lipid lowering, not just antihypertensives, may lead to a reduction in WMH growth in the eighth decade of life.