Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies
Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies
复制标题
单克隆抗体被动转移对棉鼠呼吸道合胞病毒感染的保护作用
DOI：
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发表时间：
1984
影响因子：
3.1
通讯作者：
M. W. Brandriss
中科院分区：
文献类型：
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作者：
E. Walsh;J. Schlesinger;M. W. Brandriss
被动的影响管理中和单克隆抗体(MAB)呼吸道合胞体病毒糖蛋白(GP90和VP70)是评价棉花老鼠与呼吸道合胞体病毒的挑战。注射MAB到VP70的动物在肺组织中的平均病毒滴度比对照组低（log10 2.5对5.4 PFU/g， P小于0.001），注射MAB到GP90的棉花大鼠也是如此（log10 2.1对5.0 PFU/g， P小于0.001）。在给予单克隆抗体的动物中，有50%的动物肺组织中没有检测到病毒，而在所有对照动物的肺中都检测到病毒。在两种单克隆抗体的受体中，病毒在鼻鼻甲的生长减少，但没有消除。
The effects of passive administration of neutralizing monoclonal antibodies (MAB) to respiratory syncytial virus glycoproteins (GP90 and VP70) was evaluated in cotton rats challenged with respiratory syncytial virus. Animals injected with MAB to VP70 had lower mean viral titers in lung tissues than did controls (log10 2.5 versus 5.4 PFU/g; P less than 0.001), as did cotton rats given MAB to GP90 (log10 2.1 versus 5.0 PFU/g; P less than 0.001). Fifty percent of animals given either MAB had no detectable virus in lung tissues, whereas virus was detected in the lungs of all controls. Virus growth in nasal turbinates was decreased but not eliminated in recipients of either MAB.
影响因子：
3.7
作者：
Salehi, Sattar;Ghazizadeh, Mohammadreza Jalili;Tabesh, Massoud
通讯作者：
Tabesh, Massoud