Neural Correlates of Overcoming Interference from Instructed and Implemented Stimulus-Response Associations
Neural Correlates of Overcoming Interference from Instructed and Implemented Stimulus-Response Associations
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DOI：
10.1523/jneurosci.5259-08.2009
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发表时间：
2009-02-11
影响因子：
5.3
通讯作者：
Waszak, Florian
中科院分区：
文献类型：
--
作者：
Brass, Marcel;Wenke, Dorit;Waszak, Florian
人类灵长类动物在运动领域的主要进化进步之一是他们能够使用语言指令来指导他们的行为。尽管语言信息在我们的行为调节中扮演着重要的角色，但人们对语言指令转化为有效行为的功能和神经机制仍然知之甚少。为了更深入地了解口头指令的运动表征，我们研究了涉及克服刺激反应（S-R）映射干扰的神经回路，刺激反应映射仅仅是指示的，S-R映射是实现的。与中性条件相比，实施和指导的S-R映射显示了部分重叠的大脑额顶叶活动模式。然而，直接对比显示，在执行条件下，ACC、双侧顶叶下皮层、小脑和中央前沟的激活明显增强。这表明指示的S-R映射与实现的S-R映射共享一些属性，但它们缺乏实现映射的运动相关属性。
One of the major evolutionary advances of human primates in the motor domain is their ability to use verbal instructions to guide their behavior. Despite this fundamental role of verbal information for our behavioral regulation, the functional and neural mechanisms underlying the transformation of verbal instructions into efficient behavior are still poorly understood. To gain deeper insights into the motor representation of verbal instructions, we investigated the neural circuits involved in overcoming interference from stimulus response (S-R) mappings that are merely instructed and S-R mappings that are implemented. Implemented and instructed S-R mappings revealed a partly overlapping pattern of fronto-parietal brain activity when compared with a neutral condition. However, the direct contrast revealed a clear difference with stronger activation for the implemented condition in the ACC, bilateral inferior parietal cortex, the cerebellum and the precentral sulcus. This indicates that instructed S-R mappings share some properties with implemented S-R mappings but that they are lacking the motor-related properties of implemented mappings.