Positive selection on the killer whale mitogenome
Positive selection on the killer whale mitogenome
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DOI：
10.1098/rsbl.2010.0638
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发表时间：
2011-02-23
期刊：
影响因子：
3.3
通讯作者：
da Fonseca, Rute R.
中科院分区：
文献类型：
--
作者：
Foote, Andrew D.;Morin, Phillip A.;da Fonseca, Rute R.
线粒体产生了真核细胞高达95%的能量。因此，线粒体DNA的编码基因可能会因代谢需要而在选择下进化。虎鲸，Orcinus orca，是多态的，有全球性的分布，并占据了一系列的生态位。因此，它是检验这一假设的合适微生物。我们比较了139个个体的完整线粒体基因组的全球数据集，这些数据集与激进的物理化学性质变化相关，并受到正选择的影响。两个这样的选择非同义氨基酸的变化被发现，一个在两个生态型，居住在南极浮冰。这两种取代都与局部极性的变化、空间限制的增加和可能影响整体代谢性能的α-螺旋趋势相关，表明功能变化。
Mitochondria produce up to 95 per cent of the eukaryotic cell's energy. The coding genes of the mitochondrial DNA may therefore evolve under selection owing to metabolic requirements. The killer whale, Orcinus orca, is polymorphic, has a global distribution and occupies a range of ecological niches. It is therefore a suitable organism for testing this hypothesis. We compared a global dataset of the complete mitochondrial genomes of 139 individuals for amino acid changes that were associated with radical physico-chemical property changes and were influenced by positive selection. Two such selected non-synonymous amino acid changes were found; one in each of two ecotypes that inhabit the Antarctic pack ice. Both substitutions were associated with changes in local polarity, increased steric constraints and alpha-helical tendencies that could influence overall metabolic performance, suggesting a functional change.