Merkel cell carcinoma: Prognosis and treatment of patients from a single institution
Merkel cell carcinoma: Prognosis and treatment of patients from a single institution
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DOI：
10.1200/jco.2005.02.329
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发表时间：
2005-04-01
影响因子：
45.3
通讯作者：
Coit, DG
中科院分区：
文献类型：
--
作者：
Allen, PJ;Bowne, WB;Coit, DG
目的默克尔细胞癌（MCC）是一种少见的皮肤恶性肿瘤.大多数报告由少于30例患者的单机构经验组成。MCC的自然史定义不清。患者和方法回顾了纪念斯隆-凯特琳癌症中心的MCC数据库，确定了1970年至2002年期间接受治疗的251例患者。患者，肿瘤和治疗相关因素进行了分析，其与复发和survival.Results的所有患者的平均随访时间为40个月和46个月的患者在最后一次随访中存活。5年疾病特异性生存率为64%。疾病分期是生存率的唯一独立预测因素（1期，81%; 11期，67%; 111期，52%; IV期，11%; P = 0.001）。在177例临床阴性淋巴结的患者中，71例（40%）进行了引流淋巴结盆的病理分期，其中16例（23%）发现淋巴结阳性。病理淋巴结分期与提高分期特异性生存概率（临床淋巴结阴性，75%对病理淋巴结阴性，97%; P = 0.009）和降低淋巴结复发率（44%对11%，P
Purpose Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports consist of single-institution experiences of fewer than 30 patients. The natural history of MCC is poorly defined. Patients andMethods A review was performed of Memorial Sloan-Kettering Cancer Center's MCC database, identifying 251 patients who had been treated between 1970 and 2002. Patient, tumor, and treatment-related factors were analyzed for their association with recurrence and survival.Results The average follow-up for all patients was 40 months and 46 months for patients alive at last follow-up. The 5-year disease-specific survival rate was 64%. Disease stage was the only independent predictor of survival (stage 1, 81 %; stage 11, 67%; stage 111, 52%; stage IV, 11 %; P =.001). Pathologic staging of the draining nodal basin was performed in 71 (40%) of 177 patients who presented with clinically negative nodes, and 16 of these patients (23%) were found to have node-positive disease. Pathologic nodal staging was associated with improved stage-specific survival probabilities (clinical node-negative, 75% v pathologic node-negative disease, 97%; P =.009) and decreased nodal recurrence (44% v 11%, P