Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia
Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia
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DOI：
10.1001/archpsyc.58.5.466
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发表时间：
2001-05-01
影响因子：
--
通讯作者：
Lewis, DA
中科院分区：
文献类型：
--
作者：
Pierri, JN;Volk, CLE;Lewis, DA
背景资料：精神分裂症与工作记忆缺陷有关，工作记忆是一种认知功能，依赖于前额叶皮层（PFC）与丘脑和其他皮质区域的连接。PFC深层3的锥体神经元在丘脑皮质和皮质皮质回路中都起着重要作用。考虑到染色体大小往往与神经元的树突和轴突结构相关，精神分裂症中这些回路的异常可能与深层3锥体神经元的染色体大小变化相关。我们采用基于设计的体视学方法对28例精神分裂症患者PFC 9区深层3锥体神经元的体积进行了测量，每个人都匹配到一个正常的比较主题的性别，年龄，和postmortem interval.Results：在精神分裂症的主体的体体积估计的几何平均值显着（P= 0.02）减少了9.2%。这种减少与体体积分布向较小尺寸的转变有关。无论是抗精神病药物治疗史，也没有持续时间的疾病与体size.Conclusions：这些研究结果独立复制以前的报告，减少体的大小在PFC精神分裂症。深层3锥体神经元尺寸的减少与丘脑皮质和皮质皮质回路的异常一致，表明这些回路的破坏可能导致精神分裂症的认知异常。
Background: Schizophrenia is associated with deficits in working memory, a cognitive function that depends on the connections of the prefrontal cortex (PFC) with the thalamus and other cortical regions. Pyramidal neurons in PFC deep layer 3 play a central role in both thalamocortical and corticocortical circuitry. Given that somal size tends to be associated with both the dendritic and axonal architecture of a neuron, abnormalities in these circuits in schizophrenia may be associated with a change in the somal size of deep layer 3 pyramidal neurons.Methods: We used design-based stereology to estimate the somal volume of pyramidal neurons in deep layer 3 of PFC area 9 in 28 subjects with schizophrenia, each of whom was matched to 1 normal comparison subject for sex, age, and postmortem interval.Results: The geometric mean of the somal volume estimates in the subjects with schizophrenia was significantly (P=.02) decreased by 9.2%. This decrease was associated with a shift in the distribution of somal volumes toward smaller sizes. Neither antipsychotic medication treatment history nor duration of illness was associated with somal size.Conclusions: These findings independently replicate previous reports of decreased somal size in the PFC in schizophrenia. The reduction in size of deep layer 3 pyramidal neurons is consistent with abnormalities in thalamocortical and corticocortical circuitry, suggesting that disruption of these circuits may contribute to cognitive abnormalities in schizophrenia.