Boys with precocious or early puberty: incidence of pathological brain magnetic resonance imaging findings and factors related to newly developed brain lesions.
Boys with precocious or early puberty: incidence of pathological brain magnetic resonance imaging findings and factors related to newly developed brain lesions.
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DOI：
10.6065/apem.2013.18.4.183
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发表时间：
2013-12-01
影响因子：
2.2
通讯作者：
Yang, Sei Won
中科院分区：
文献类型：
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作者：
Choi, Keun Hee;Chung, Seung Joon;Yang, Sei Won
目的：研究性早熟(PP)和青春期早期(EP)男童的脑部磁共振成像(MRI)表现及预测脑部病变的因素。PP分为中心型和周围型。脑MRI表现分为I组(已知引起青春期的病理性脑损害；新诊断的[Ia组]或以前诊断的[Ib组])；II组(可能与青春期有关的脑损害)；III组(偶然或正常发现)。结果：中枢性PP组23例中17例(74%)，EP组30例中9例(30%)，外周性PP组8例中7例(88%)。外周性PP患儿的脑部病变均为生殖细胞肿瘤(GCT)，3个病变在随访过程中发生。I组青春期发育期提前(P
PURPOSE: Brain magnetic resonance imaging (MRI) findings and factors predictive of pathological brain lesions in boys with precocious puberty (PP) or early puberty (EP) were investigated.METHODS: Sixty-one boys with PP or EP who had brain MRI performed were included. PP was classified into the central or peripheral type. Brain MRI findings were categorized into group I (pathological brain lesion known to cause puberty; newly diagnosed [group Ia] or previously diagnosed [group Ib]); group II (brain lesion possibly related to puberty); and group III (incidental or normal findings). Medical history, height, weight, hormone test results, and bone age were reviewed.RESULTS: Brain lesions in groups I and II were detected in 17 of 23 boys (74%) with central PP, 9 of 30 boys (30%) with EP, and 7 of 8 boys (88%) with peripheral PP. All brain lesions in boys with peripheral PP were germ cell tumors (GCT), and 3 lesions developed later during follow-up. Group I showed earlier pubertal onset (P