Cortico-subcortical β burst dynamics underlying movement cancellation in humans.
Cortico-subcortical β burst dynamics underlying movement cancellation in humans.
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DOI：
10.7554/elife.70270
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发表时间：
2021-12-07
期刊：
影响因子：
7.7
通讯作者：
Wessel JR
中科院分区：
文献类型：
--
作者：
Diesburg DA;Greenlee JD;Wessel JR
主流神经解剖学模型认为，人类通过环状皮质-皮层下网络调节运动，包括丘脑下核（STN）、运动丘脑和感觉运动皮层（SMC）。据称，这些网络中的抑制命令是通过β频率（15-29 Hz）的瞬时突发信号发送的。然而，由于人类深度记录研究通常局限于一个记录地点，因此迄今为止缺乏这一主张的直接证据。在这里，我们展示了在人类执行停止信号任务时，来自SMC和STN或运动丘脑的同时多位点记录。与它们作为抑制信号的功能一致，皮层下β-爆发在成功的停止试验中增加。特别是在STN爆发后的50 ms内，SMC上的β-爆发增加。此外，位点间比较（包括同时记录SMC、丘脑和STN的患者）证实，STN的β-爆发在时间上先于丘脑的β-爆发。这组高度独特的记录为β-爆发在传递抑制命令方面的作用提供了经验证据，这些抑制命令沿着长期提出的皮层-皮层下网络在人类运动调节中发挥作用。
Dominant neuroanatomical models hold that humans regulate their movements via loop-like cortico-subcortical networks, which include the subthalamic nucleus (STN), motor thalamus, and sensorimotor cortex (SMC). Inhibitory commands across these networks are purportedly sent via transient, burst-like signals in the β frequency (15–29 Hz). However, since human depth-recording studies are typically limited to one recording site, direct evidence for this proposition is hitherto lacking. Here, we present simultaneous multi-site recordings from SMC and either STN or motor thalamus in humans performing the stop-signal task. In line with their purported function as inhibitory signals, subcortical β-bursts were increased on successful stop-trials. STN bursts in particular were followed within 50 ms by increased β-bursting over SMC. Moreover, between-site comparisons (including in a patient with simultaneous recordings from SMC, thalamus, and STN) confirmed that β-bursts in STN temporally precede thalamic β-bursts. This highly unique set of recordings provides empirical evidence for the role of β-bursts in conveying inhibitory commands along long-proposed cortico-subcortical networks underlying movement regulation in humans.