Executive and social behaviors under nicotinic receptor regulation
Executive and social behaviors under nicotinic receptor regulation
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DOI：
10.1073/pnas.1533498100
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发表时间：
2003-08-05
影响因子：
11.1
通讯作者：
Changeux, JP
中科院分区：
文献类型：
--
作者：
Granon, S;Faure, P;Changeux, JP
尼古丁增强了几种认知和精神行为，尼古丁拮抗剂导致需要认知努力的任务受损。为了探索烟碱受体对复杂认知功能的贡献，我们开发了一种自动化方法来研究小鼠的顺序运动行为和社会行为分析。我们发现，在β 2（-/-）突变体，高阶时空组织的运动行为，连同冲突解决和社会互动，是选择性地从低层次的，更自动的运动行为。这种执行功能的缺陷类似于在某些精神病理学障碍中发现的僵硬和反社会行为，如自闭症和注意力缺陷多动障碍。
Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to complex cognitive functions, we developed an automated method to investigate sequential locomotor behavior in the mouse and an analysis of social behavior. We show that, in the beta2(-/-)mutant, the high-order spatiotemporal organization of locomotor behavior, together with conflict resolution and social interaction, is selectively dissociated from low-level, more automatic motor behaviors. Such deficits in executive functions resemble the rigid and asocial behavior found in some psychopathological disorders such as autism and attention deficit hyperactivity disorder.