Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of brown fat metabolism.
Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of brown fat metabolism.
复制标题
人体组织传热数值 3D 建模，用于微波辐射监测棕色脂肪代谢。
DOI：
10.1117/12.2004931
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Stauffer,PaulR
中科院分区：
文献类型：
--
作者：
Rodrigues,DarioB;Maccarini,PaoloF;Salahi,Sara;Colebeck,Erin;Topsakal,Erdem;Pereira,PedroJS;Limão-Vieira,Paulo;Stauffer,PaulR
研究背景棕色脂肪组织（brownadiposetissue，BAT）在全身代谢中起重要作用，可能介导体重增加和胰岛素敏感性。尽管一些成像技术允许BAT检测，但目前没有可行的方法用于连续采集BAT能量消耗。我们提出了一种非侵入性的技术，长期监测BAT的代谢，使用微波radiometry.MethodsA多层三维计算模型创建HFSSTM与1.5 mm的皮肤，3-10 mm的皮下脂肪，200 mm的肌肉和BAT区域（2-6 cm 3）位于脂肪和肌肉之间。基于此模型，对数螺旋天线的设计和优化，以最大限度地接收来自目标（BAT）的热辐射。HFSSTM中计算的功率吸收模式与COMSOL®中计算的模拟热分布相结合，以预测从超低噪声微波辐射计测量的辐射信号。天线接收的功率的特点是作为一个功能的不同水平的BAT代谢下冷和去甲肾上腺素stimulation.ResultsThe的最佳频带为1.5-2.2 GHz，平均天线效率为19%。由辐射天线接收的模拟功率增加2-9毫dBm（去甲肾上腺素刺激）和4-15毫dBm（冷刺激），对应于增加15倍BAT metabolis.ConclusionsResults证明了从小体积（2-6立方厘米）的BAT位于高达12毫米深的热辐射检测能力，并监测BAT代谢的微小变化（0.5 °C）。因此，所开发的微型辐射天线传感器似乎适合于BAT代谢的非侵入性长期监测。
BackgroundBrown adipose tissue (BAT) plays an important role in whole body metabolism and could potentially mediate weight gain and insulin sensitivity. Although some imaging techniques allow BAT detection, there are currently no viable methods for continuous acquisition of BAT energy expenditure. We present a non-invasive technique for long term monitoring of BAT metabolism using microwave radiometry.MethodsA multilayer 3D computational model was created in HFSSTMwith 1.5 mm skin, 3-10 mm subcutaneous fat, 200 mm muscle and a BAT region (2-6 cm3) located between fat and muscle. Based on this model, a log-spiral antenna was designed and optimized to maximize reception of thermal emissions from the target (BAT). The power absorption patterns calculated in HFSSTMwere combined with simulated thermal distributions computed in COMSOL® to predict radiometric signal measured from an ultra-low-noise microwave radiometer. The power received by the antenna was characterized as a function of different levels of BAT metabolism under cold and noradrenergic stimulation.ResultsThe optimized frequency band was 1.5-2.2 GHz, with averaged antenna efficiency of 19%. The simulated power received by the radiometric antenna increased 2-9 mdBm (noradrenergic stimulus) and 4-15 mdBm (cold stimulus) corresponding to increased 15-fold BAT metabolism.ConclusionsResults demonstrated the ability to detect thermal radiation from small volumes (2-6 cm3) of BAT located up to 12 mm deep and to monitor small changes (0.5 °C) in BAT metabolism. As such, the developed miniature radiometric antenna sensor appears suitable for non-invasive long term monitoring of BAT metabolism.