Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells.
Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells.
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DOI：
10.1038/s41416-021-01283-3
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发表时间：
2021-04
影响因子：
8.8
通讯作者：
Godkin A
中科院分区：
文献类型：
--
作者：
Thomson A;Bento DFC;Scurr MJ;Smart K;Somerville MS;Keita ÅV;Gallimore A;Godkin A
T细胞细胞因子谱是结直肠癌（CRC）手术后结果的关键预后指标。虽然CRC中产生的TH 1（IFN-γ+）细胞介导的应答被充分记录并且与改善的存活相关，但抗原特异性TH 17（IL-17 A+）应答尚未被类似地测量。我们试图确定34例CRC患者的循环肿瘤抗原-（5 T4/CEA）特异性T细胞的细胞因子谱，以解决抗原特异性IL-17 A应答是否可检测以及这些应答是否不同于IFN-γ应答。与产生IFN-γ的T细胞一样，抗5 T4/CEA TH 17应答主要在早期（TNM I/II）CRC患者中可检测到。此外，虽然IL-17 A总是与IFN-γ联合产生，但这种释放主要来自两种不同的T细胞群体，而不是由“双重产生”T细胞产生。肿瘤特异性TH 1 +/TH 17+应答的患者表现出延长的无复发生存期。肿瘤抗原特异性TH 17应答在预防结直肠肿瘤术后复发中发挥有益作用。
The T cell cytokine profile is a key prognostic indicator of post-surgical outcome for colorectal cancer (CRC). Whilst TH1 (IFN-γ+) cell-mediated responses generated in CRC are well documented and are associated with improved survival, antigen-specific TH17 (IL-17A+) responses have not been similarly measured. We sought to determine the cytokine profile of circulating tumour antigen-(5T4/CEA) specific T cells of 34 CRC patients to address whether antigen-specific IL-17A responses were detectable and whether these were distinct to IFN-γ responses. As with IFN-γ-producing T cells, anti-5T4/CEA TH17 responses were detectable predominantly in early stage (TNM I/II) CRC patients. Moreover, whilst IL-17A was always produced in association with IFN-γ, this release was mainly from two distinct T cell populations rather than by ‘dual producing’ T cells. Patients mounting both tumour-specific TH1+/TH17+ responses exhibited prolonged relapse-free survival. Tumour antigen-specific TH17 responses play a beneficial role in preventing post-operative colorectal tumour recurrence.
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影响因子：
11.2
作者：
Tosolini, Marie;Kirilovsky, Amos;Galon, Jerome
通讯作者：
Galon, Jerome
影响因子：
10.3
作者：
Scurr, Martin J.;Brown, Clare M.;Godkin, Andrew
通讯作者：
Godkin, Andrew
肿瘤浸润 T 辅助细胞 17 在人类结直肠癌中的双重作用。
影响因子：
24.5
作者：
Amicarella F;Muraro MG;Hirt C;Cremonesi E;Padovan E;Mele V;Governa V;Han J;Huber X;Droeser RA;Zuber M;Adamina M;Bolli M;Rosso R;Lugli A;Zlobec I;Terracciano L;Tornillo L;Zajac P;Eppenberger-Castori S;Trapani F;Oertli D;Iezzi G
通讯作者：
Iezzi G
影响因子：
8.8
作者：
Laheurte, Caroline;Dosset, Magalie;Adotevi, Olivier
通讯作者：
Adotevi, Olivier
影响因子：
12.4
作者：
Parkhurst, Maria R.;Yang, James C.;Rosenberg, Steven A.
通讯作者：
Rosenberg, Steven A.