Cytogenetic and molecular cytogenetic analyses in diffuse astrocytomas
Cytogenetic and molecular cytogenetic analyses in diffuse astrocytomas
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DOI：
10.1016/j.cancergencyto.2003.12.017
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发表时间：
2004-08-01
影响因子：
--
通讯作者：
Froster, UG
中科院分区：
文献类型：
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作者：
Krupp, W;Geiger, K;Froster, UG
弥漫性星形细胞瘤是高度可变的肿瘤，并显示出基于多步骤肿瘤发生的复杂生物学行为。我们报告23例弥漫性星形细胞瘤的细胞遗传学和分子细胞遗传学研究。报道了常规核型分析、间期荧光原位杂交（FISH）、比较基因组杂交、荧光原位杂交和光谱核型分析的结果。鉴定了各种数量和结构染色体畸变。在2号染色体短臂（2p）和7号染色体长臂（7q）检测到聚集的结构改变。利用光谱核型分析，发现了常规方法检测不到的额外的染色体重排，其中一些异常在弥漫性星形细胞瘤中以前没有被描述过。需要对这些不一致的结果进行独立验证。(C)2004年爱思唯尔公司All rights reserved.
Diffuse astrocytomas are highly variable tumors and show complex biologic behavior that is based on multi-step oncogenesis. We report cytogenetic and molecular cytogenetic investigations in 23 cases of diffuse astrocytomas. The results of conventional karyotyping, interphase fluorescence in situ hybridization (FISH), comparative genomic hybridization, multicolor FISH, and spectral karyotyping are reported. Various numerical and structural chromosomal aberrations were identified. Clustering of structural alterations in the short arm of chromosome 2 (2p) and the long arm of chromosome 7 (7q) were detected. Using spectral karyotyping, additional chromosome rearrangements not detectable by conventional methods were found. Some of these anomalies have not been previously described in diffuse astrocytomas. An independent validation of these discrepant findings is required. (C) 2004 Elsevier Inc. All rights reserved.