REGIONAL MYOCARDIAL PERFUSION AND WALL THICKENING DURING ISCHEMIA IN CONSCIOUS DOGS
REGIONAL MYOCARDIAL PERFUSION AND WALL THICKENING DURING ISCHEMIA IN CONSCIOUS DOGS
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DOI：
10.1152/ajpheart.1984.247.5.h727
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发表时间：
1984-01-01
影响因子：
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通讯作者：
ROSS, J
中科院分区：
文献类型：
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作者：
GALLAGHER, KP;MATSUZAKI, M;ROSS, J
在清醒犬中，通过测量收缩期室壁增厚（%WT），观察了跨室壁3个不同层心肌血流量（MBF）减少对缺血区局部心肌收缩功能的影响。在16只狗中，在左回旋支冠状动脉的冠状动脉狭窄期间，用超声显微测量法测量%WT，并用微球（直径10- 12 μ m）测定MBF。根据对%WT的影响将狭窄分为6组（每组代表%WT相对于对照组的20%递减），并对来自6只具有多个数据点的犬的数据进行个体和合并回归分析，以评价MBF与%WT变化之间关系的形状（线性或曲线）。心室收缩功能对MBF的急性降低高度敏感，尤其是内膜下MBF的降低。经回归分析，标准化内膜下MBF-%WT关系呈轻度曲线（二次方程，y =-0.75x ~2 + 2.15x ~（-0.39），r ~ 2 = 0.92）。平均透壁和中层心肌MBF与%WT的变化密切相关。心外膜下MBF与%WT的变化相关性较差，直到%WT降低超过50%，心外膜下MBF才发生变化。
In conscious dogs the effects of reductions in myocardial blood flow (MBF) in 3 different layers across the wall on regional myocardial contractile function in the ischemic zone, measured as systolic wall thickening (%WT). In 16 dogs, %WT was measured with sonomicrometry and MBF was determined with microspheres (10- to 12-.mu.m diameter) during coronary stenosis of the left circumflex coronary artery. The stenoses were categorized into 6 groups by the effect on %WT (each group representing progressive 20% decrements in %WT from control), and individual and pooled regression analyses were performed on data from 6 of the dogs having multiple data points to evaluate the shape (linear or curvilinear) of the relationships between MBF and changes in %WT. Transmural contractile function was highly sensitive to acute reductions in MBF, especially reductions in the subendocardium. The shape of the normalized subendocardial MBF-%WT relation was mildly curvilinear by regression analysis (quadratic equation, y = -0.75x2 + 2.15x -0.39, r2 = 0.92). Mean transmural and midmyocardial MBF correlated well and closely with changes in %WT. Subepicardial MBF correlated poorly with changes in %WT, there being no change in subepicardial MBF until %WT was reduced more than 50%.