The intercalated disc: a mechanosensing signalling node in cardiomyopathy.
The intercalated disc: a mechanosensing signalling node in cardiomyopathy.
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DOI：
10.1007/s12551-020-00737-x
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发表时间：
2020-08-01
影响因子：
--
通讯作者：
Ehler, Elisabeth
中科院分区：
文献类型：
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作者：
Pruna, Mihai;Ehler, Elisabeth
心肌细胞是在心脏中产生收缩力的细胞，通过高度专业化的结构，即闰盘（ID）相互连接，这确保了相邻细胞之间的力传递和转导，并允许心肌同步发挥作用。此外，心肌细胞具有感知机械变化并相应地调节其自身收缩输出的内在能力。为了实现这一目标，一些负责力传递的组件已经进化到能够感知张力的变化，并触发导致心肌细胞分子和细胞变化的生化反应。这在心肌病中变得特别重要，其中心脏暴露于增加的机械负荷并且需要适应以维持其收缩功能。在这篇综述中，我们将讨论目前在闰盘的关键mechanosensing元素，并提供了一个概述的信号分子参与介导的机械力的变化的反应。
Cardiomyocytes, the cells generating contractile force in the heart, are connected to each other through a highly specialised structure, the intercalated disc (ID), which ensures force transmission and transduction between neighbouring cells and allows the myocardium to function in synchrony. In addition, cardiomyocytes possess an intrinsic ability to sense mechanical changes and to regulate their own contractile output accordingly. To achieve this, some of the components responsible for force transmission have evolved to sense changes in tension and to trigger a biochemical response that results in molecular and cellular changes in cardiomyocytes. This becomes of particular importance in cardiomyopathies, where the heart is exposed to increased mechanical load and needs to adapt to sustain its contractile function. In this review, we will discuss key mechanosensing elements present at the intercalated disc and provide an overview of the signalling molecules involved in mediating the responses to changes in mechanical force.