ROLE OF PLASMIN IN KININ-RELEASE BY PREPARATIONS OF HUMAN THROMBIN

ROLE OF PLASMIN IN KININ-RELEASE BY PREPARATIONS OF HUMAN THROMBIN
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DOI:
10.1016/0049-3848(79)90087-2
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发表时间:
1979-01-01
影响因子:
7.5
通讯作者:
KLENIEWSKI, J
KLENIEWSKI, J
中科院分区:
医学3区
文献类型:
--
作者:
DONALDSON, VH;KLENIEWSKI, J

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A preparation of human .alpha.-thrombin previously reported to release kinin from human high MW kininogen was contaminated with small amounts of plasminogen and plasmin which were probably responsible for kinin release. Inhibitors of plasmin which did not inhibit thrombin clotting activity blocked kinin release and removal of plasminogen from the thrombin depleted the preparation of kinin-releasing activity.