Protective role of oral antioxidant supplementation in ocular surface of diabetic patients
Protective role of oral antioxidant supplementation in ocular surface of diabetic patients
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DOI：
10.1136/bjo.86.12.1369
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发表时间：
2002-12-01
影响因子：
4.1
通讯作者：
Sitaras, NM
中科院分区：
文献类型：
--
作者：
Peponis, V;Papathanasiou, M;Sitaras, NM
目的：为探讨维生素C和维生素E对2型糖尿病患者亚硝酸盐、一氧化氮（NO）相关代谢产物水平及眼表参数的影响，对50例2型糖尿病患者分别给予维生素C（1000 mg/d）和维生素E（400 IU/d）补充治疗10 d。在维生素补充前后，通过光度测定法测量泪液中的亚硝酸盐水平。泪液功能参数（Schirmer试验I、BUT、眼蕨试验）和结膜上皮刷状细胞学分析也进行了评价。
Aim: To investigate the effect of vitamin C and E supplementation in the levels of nitrite, nitric oxide (NO) related metabolite, and ocular surface parameters in diabetic patients.Methods: 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) supplementation for 10 days. Nitrite levels in tears were measured by photometric determination before and after vitamin supplementation. Tear function parameters (Schirmer test I, BUT, ocular ferning test) and brush cytology analysis of the conjunctival epithelium were also evaluated.Results: Nitrite levels were found to be significantly reduced (p