The return of Ehrlich's 'Therapia magna sterilisans' and other Ehrlich concepts?: Series of papers honoring Paul!Ehrlich on the occasion of his 150th birthday
The return of Ehrlich's 'Therapia magna sterilisans' and other Ehrlich concepts?: Series of papers honoring Paul!Ehrlich on the occasion of his 150th birthday
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DOI：
10.1159/000077277
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发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
Sörgel, F
中科院分区：
文献类型：
--
作者：
Sörgel, F
今年3月14日，伟大的德国研究者、“化学疗法的创始人”保罗·埃利希诞辰150周年。有趣的是，他后来的同事埃米尔·冯·贝林在1854年晚一天出生。两人都是罗伯特·科赫实验室的同事，都获得了诺贝尔奖（因为他们在免疫学方面的工作），在抗感染治疗方面做出了巨大贡献。埃米尔·冯·贝林（Emil von Behring）的方法是通过使用免疫制剂，而埃利希（Ehrlich）则倾向于使用化学制剂进行抗感染治疗。通过一个巧妙的概念，他发现了第一种化疗药物，这显然是他早期对染料研究的延续。从他的染色工作中，他得出了以下结论：如果有染料可以用来染色细胞，为什么不开发一种药理制剂，像染料一样，也能附着在活病原体的结构上并杀死它们。他给这些特工起了一个充满感情的名字“魔弹”。这篇介绍性综述将在Ehrlich诞辰150周年和将于2004年9月9日至11日在德国纽伦堡举行的“世界抗感染药物剂量会议：给魔弹剂量”之际发表一系列论文（见www.ehrlich2004.org）。除了会议主题之外，这次会议还将纪念一位上世纪真正的科学巨人，同时也是一位谦虚的人，正如罗伯特·科赫所说，“人们必须喜欢他”。本文回顾了埃利希的巧妙概念，包括现代梅毒治疗，幽门螺杆菌感染的单剂量治疗（“大无菌治疗”），砷化合物三氧化二砷的引入，以及关于刚果红（一种著名的“非埃利希染料”）的实验和令人兴奋的新数据。版权所有(C) 2004 S. Karger AG，巴塞尔。
On March 14th of this year, the birthday of Paul Ehrlich, the great German researcher and 'founder of chemotherapy', returned for the 150th time. Interestingly, his later colleague Emil von Behring was born one day later in 1854. Both were coworkers in Robert Koch's laboratory and became Nobel Prize laureates (for their work in immunology), making great contributions to antiinfectious treatments. Emil von Behring's approach was through the use of immunological agents, while Ehrlich favored an approach of antiinfectious treatment by chemical agents. Through an ingenious concept that was a clear continuation of his early days in research with dyes, he found the first chemotherapeutic agents. From his dye work, he had concluded the following: if there are dyes that one can use to stain cells, why not develop pharmacological agents that, like stains, also attach to a structure in the living pathogen and kill them. He gave these agents the emotionally charged name 'magic bullets'. This introductory review will initiate a series of papers on the occasion of Ehrlich's 150th birthday and the 'World Conference on Dosing of Antiinfectives: Dosing the Magic Bullets', which is going to be held in Nurnberg, Germany, from September 9 to 11, 2004 (see www.ehrlich2004.org). Apart from the conference topic, this conference will also commemorate a real science giant of the last century and yet a modest human being whom, as Robert Koch put it, 'one had to like'. This article recalls Ehrlich's ingenious concepts, including modern syphilis treatment, one-dose treatment ('therapia magna sterilisans') of Helicobacter pylori infections and introduction of an arsenic compound, arsenic trioxide, as well as experiments and new exciting data on Congo red, a well-known 'non-Ehrlich dye'. Copyright (C) 2004 S. Karger AG, Basel.