Associations among family history of cancer, cancer screening and lifestyle behaviors: a population-based study
Associations among family history of cancer, cancer screening and lifestyle behaviors: a population-based study
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DOI：
10.1007/s10552-013-0226-9
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发表时间：
2013-08-01
影响因子：
2.3
通讯作者：
McCarthy, William J.
中科院分区：
文献类型：
--
作者：
Bostean, Georgiana;Crespi, Catherine M.;McCarthy, William J.
一些癌症在很大程度上是可以通过改变某些行为风险因素和预防性筛查来预防的，即使是那些有癌症家族史的人。本研究调查了（1）家族癌症史和癌症筛查之间的关系，（2）家族癌症史和癌症预防生活方式行为之间的关系，以及（3）癌症筛查和生活方式行为之间的关系。数据来自2009年加州健康访谈调查（n = 12，603）。结果包括乳腺癌（BC）和结直肠癌（CRC）的筛查以及基于世界癌症研究基金会建议的六种癌症预防生活方式。多变量逻辑回归分析，按性别和种族-民族分层，检查相关性。预测的癌症筛查的概率由家族癌症史，种族，种族，和sexy.Family历史的特定部位的癌症-CRC的男性和女性，和BC的女性-与癌症筛查的概率较高的大多数群体，特别是CRC，但在很大程度上是无关的其他生活方式行为。在少数家族史与生活方式显著相关的病例中，例如，白色和拉丁美洲男性的体育活动，白色和亚洲女性的吸烟，有家族史的个体比没有家族史的个体遵守建议的几率要低。在白色和亚洲男性中，更大程度地遵守生活方式建议与更高的最新CRC筛查几率相关，而亚洲女性中的几率较低（与BC筛查无显著关联）;这种关系并不因家族癌症史而改变。2家族癌症史与更好的生活方式行为无关这一事实可能反映了家族内共同的行为风险，或者缺乏关于某些生活方式行为如何影响个人癌症风险的知识。研究结果可以为因家族史而增加癌症风险的个人提供旨在改变生活方式行为的干预措施。
Some cancers are largely preventable through modification of certain behavioral risk factors and preventive screening, even among those with a family history of cancer. This study examined the associations between (1) family cancer history and cancer screening, (2) family history and cancer preventive lifestyle behaviors, and (3) cancer screening and lifestyle behaviors.Data were from the 2009 California Health Interview Survey (n = 12,603). Outcomes included screening for breast cancer (BC) and colorectal cancer (CRC) and six cancer preventive lifestyle behaviors, based on World Cancer Research Fund recommendations. Multivariate logistic regression analyses, stratified by gender and race-ethnicity, examined associations. Predicted probabilities of cancer screening by family cancer history, race-ethnicity, and sex were computed.Family history of site-specific cancer-CRC for men and women, and BC for women-was associated with higher probability of cancer screening for most groups, especially for CRC, but was largely unrelated to other lifestyle behaviors. In the few cases in which family history was significantly associated with lifestyle-for example, physical activity among White and Latino males, smoking among White and Asian females-individuals with a family history had lower odds of adherence to recommendations than those with no family history. Greater overall adherence to lifestyle recommendations was associated with higher odds of up-to-date CRC screening among White and Asian males, and lower odds among Asian females (no significant association with BC screening); this relationship did not vary by family cancer history.The fact that family history of cancer is not associated with better lifestyle behaviors may reflect shared behavioral risks within families, or the lack of knowledge about how certain lifestyle behaviors impact personal cancer risk. Findings can inform interventions aimed at lifestyle behavioral modification for individuals at increased cancer risk due to family history.