The effect of antibacterial monomer MDPB on the growth of organisms associated with root caries
The effect of antibacterial monomer MDPB on the growth of organisms associated with root caries
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DOI：
10.4012/dmj.26.388
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发表时间：
2007-05-01
影响因子：
2.5
通讯作者：
Momov, Yasuko
中科院分区：
文献类型：
--
作者：
Yoshikawa, Kazushi;Clark, Douglas T.;Momov, Yasuko
测试MDPB（12-甲基丙烯酰氧基十二烷基溴化吡啶）抑制与活动性根龋病变相关的生物体的生长并在亚MIC下改变这些生物体的生长特征的能力。MDPB的MIC和MBC用于以下分类群的独立分离株（n=5）：变形链球菌，口腔链球菌，唾液链球菌，内氏放线菌，以色列放线菌，Gerensceriae放线菌，溶牙放线菌，乳杆菌属，和白色念珠菌进行测定，并评估在亚MIC下对微生物生长动力学的影响。所有菌株均对MDPB的抑制作用敏感。MDPB对这些微生物的中位MIC和MBC范围分别为3.13 - 25.0 μ g/ml和6.25 - 50.0 μ g/ml。至于pH值的影响，抑制是敏感的酸性pH值。即使在亚MIC，所有菌株的生长，测量细胞产量和倍增时间，显着减少。根据本研究的结果，MDPB显示出抑制与活动性根龋病变相关的微生物群生长的潜力。
MDPB, 12-methacryloyloxydodecylpyridinium bromide, was tested for its ability to inhibit the growth of organisms associated with active root caries lesions and to modify the growth characteristics of these organisms at sub-MICs. MICs and MBCs of MDPB for independent isolates (n=5) of the following taxa: Streptococcus mutans, Streptococcus oralis, Streptococcus salivarius, Actinomyces naeslundii, Actinomyces israelii, Actinomyces gerensceriae, Actinomyces odontolyticus, Lactobacillus spp., and Candida albicans were determined, and the effects at sub-MIC on microbial growth kinetics were assessed. All isolates were sensitive to inhibition by MDPB. The median MICs and MBCs of MDPB for these organisms were in the range of 3.13 to 25.0 mu g/ml and 6.25 to 50.0 mu g/ml, respectively. As for the influence of pH, inhibition was sensitive to acidic pH. Even at sub-MICs, the growth of all strains, measured as cell yield and doubling time, was significantly reduced. Based on the results of this study, MDPB exhibited the potential to inhibit the growth of microbiota associated with active root caries lesions.