Reduced Coffee Consumption Among Individuals With Primary Sclerosing Cholangitis but Not Primary Biliary Cirrhosis
Reduced Coffee Consumption Among Individuals With Primary Sclerosing Cholangitis but Not Primary Biliary Cirrhosis
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DOI：
10.1016/j.cgh.2013.12.036
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发表时间：
2014-09-01
影响因子：
12.6
通讯作者：
Lazaridis, Konstantinos N.
中科院分区：
文献类型：
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作者：
Lammert, Craig;Juran, Brian D.;Lazaridis, Konstantinos N.
背景与目的：饮用咖啡与降低肝病风险及相关结果有关。然而，在胆汁淤积性自身免疫性肝病、原发性胆汁性肝硬化症(PBC)或原发性硬化性胆管炎(PSC)的患者中，喝咖啡的情况还没有被研究过。方法：通过对606名PBC患者、480名PSC患者和564名健康志愿者(对照组)的问卷调查，确定他们终生饮用咖啡的习惯。采用连续变量的Wilcoxon秩和检验和离散变量的c(2)方法对PBC和PSC患者与对照组进行比较。在调整了年龄、性别、吸烟状况和教育水平后，采用Logistic回归分析了不同咖啡参数(时间、频率和咖啡消费类型)的影响估计。结果：PBC患者和对照组的咖啡参数没有差异。然而，24%的PSC患者从未喝过咖啡，而对照组只有16%(P<；0.05)，只有67%的人现在喝咖啡，而对照组的77%(P<；0.05)。患有PSC的患者每月饮用的终生杯子也较少(45杯比47杯，P<；0.05)，一生中喝咖啡的比例也更低(46.6%比66.7%，P<；0.05)。在多变量模型中，这些差异仍然显著。在并发溃疡性结肠炎的PSC患者中，咖啡对直肠切除有保护作用(风险比，0.34；P<；.001)。结论：与对照组相比，PSC患者的咖啡消耗量较低，但PBC患者没有。
BACKGROUND & AIMS: Coffee consumption has been associated with decreased risk of liver disease and related outcomes. However, coffee drinking has not been investigated among patients with cholestatic autoimmune liver diseases, primary biliary cirrhosis (PBC), or primary sclerosing cholangitis (PSC). We investigated the relationship between coffee consumption and risk of PBC and PSC in a large North American cohort.METHODS: Lifetime coffee drinking habits were determined from responses to questionnaires from 606 patients with PBC, 480 with PSC, and 564 healthy volunteers (controls). Patients (those with PBC or PSC) were compared with controls by using the Wilcoxon rank sum test for continuous variables and c(2) method for discrete variables. Logistic regression was used to analyze the estimate of the effects of different coffee parameters (time, frequency, and type of coffee consumption) after adjusting for age, sex, smoking status, and education level.RESULTS: Patients with PBC and controls did not differ in coffee parameters. However, 24% of patients with PSC had never drunk coffee compared with 16% of controls (P < .05), and only 67% were current drinkers compared with 77% of controls (P < .05). Patients with PSC also consumed fewer lifetime cups per month (45 vs 47 for controls, P < .05) and spent a smaller percentage of their lifetime drinking coffee (46.6% vs 66.7% for controls, P < .05). These differences remained significant in a multivariate model. Among PSC patients with concurrent ulcerative colitis, coffee protected against proctocolectomy (hazard ratio, 0.34; P < .001).CONCLUSIONS: Coffee consumption is lower among patients with PSC, but not PBC, compared with controls.