Strain softening in stretched DNA.
Strain softening in stretched DNA.
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DOI：
10.1103/physrevlett.101.118101
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发表时间：
2008-09-12
影响因子：
8.6
通讯作者：
Aksimentiev A
中科院分区：
文献类型：
--
作者：
Luan B;Aksimentiev A
用广泛的分子动力学模拟表征了DNA拉伸的微观机制。通过采用各向异性压力控制方法，得到了有效无限大DNA分子的真实力伸长依赖关系。在超拉伸转变过程中观察到B-结构域和S-DNA域的共存。模拟结果表明，在拉伸扭转约束DNA的过程中可能会出现应变软化现象。后一种观测结果与现有的实验数据用随机场伊辛模型进行了定性的对比。
The microscopic mechanics of DNA stretching was characterized using extensive molecular dynamics simulations. By employing an anisotropic pressure control method, realistic force-extension dependences of effectively infinite DNA molecules were obtained. A coexistence of B- and S-DNA domains was observed during the overstretching transition. The simulations revealed that strain softening may occur in the process of stretching torsionally constrained DNA. The latter observation was qualitatively reconciled with available experimental data using a random-field Ising model.