Dietary supplementation with n‐3 polyunsaturated fatty acids and human platelet function: a review with particular emphasis on implications for cardiovascular disease
Dietary supplementation with n‐3 polyunsaturated fatty acids and human platelet function: a review with particular emphasis on implications for cardiovascular disease
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膳食补充剂 n-3 多不饱和脂肪酸和人血小板功能：特别强调对心血管疾病影响的综述
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Jørn Dyerberg
中科院分区：
文献类型：
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作者：
S. Kristensen;Erik Berg Schmidt;Jørn Dyerberg
抽象的。格陵兰爱斯基摩人心肌梗死发病率低可能是因为他们摄入了高含量的n-3多不饱和脂肪酸(PUFAs)的海洋食品。与年龄和性别匹配的丹麦人相比，爱斯基摩人的血小板计数降低，血小板聚集受到抑制，出血时间延长，促聚集血栓素与抗聚集前列环素的比率降低。本文综述了鱼粮或鱼油补充剂对人体血小板功能影响的研究进展。大多数研究表明，补充n-3多不饱和脂肪酸可导致抑制血小板行为。需要确定n-3多不饱和脂肪酸的最佳剂量和最有可能从补充中获益的患者组。该补充剂的安全性和临床疗效有待于长期研究。
Abstract. The low incidence of myocardial infarction in Greenland Eskimos may be due to their intake of marine food with a high content of n‐3 polyunsaturated fatty acids (PUFAs). In Eskimos the platelet count is lowered, the platelet aggregation is inhibited, the bleeding time is prolonged and the ratio between proaggregatory thromboxanes and antiaggregatory prostacyclins is decreased, when compared to age‐ and sex‐matched Danes. In this review, studies evaluating the effect of a fish diet or fish‐oil supplementation on human platelet function are summarized. Most studies have demonstrated that supplementation with n‐3 PUFAs can cause inhibition of platelet behaviour. The optimal dose of n‐3 PUFAs and the patient groups most likely to profit from supplementation need to be defined. The safety and the clinical effect of the supplementation should be investigated in long‐term studies.
二十碳五酸抑制静脉移植物内膜增厚：减少血栓素的产生，而不改变脂蛋白水平或低密度脂蛋白受体密度。
影响因子：
4.3
作者：
Cahill,PD;Sarris,GE;Cooper,AD;Wood,PD;Kosek,JC;Mitchell,RS;Miller,DC
通讯作者：
Miller,DC