MITRAL-SEPTAL SEPARATION - NEW ECHOCARDIOGRAPHIC INDEX OF LEFT-VENTRICULAR FUNCTION
MITRAL-SEPTAL SEPARATION - NEW ECHOCARDIOGRAPHIC INDEX OF LEFT-VENTRICULAR FUNCTION
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DOI：
10.1016/s0002-9149(77)80215-4
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发表时间：
1977-01-01
影响因子：
2.8
通讯作者：
PARMLEY, WW
中科院分区：
文献类型：
--
作者：
MASSIE, BM;SCHILLER, NB;PARMLEY, WW
评价二尖瓣前叶E点和室间隔之间最小分离的超声心动图测量值，作为左心室功能指标。二尖瓣间隔分离被认为是很容易测量，可重复性和独立的病人的位置或心率变化高达32次/分钟。在一组30名正常人，E点间隔分离是不存在的25和最小的（小于4毫米），在其余的5。在125例患有各种心脏疾病的患者中检查了该变量与双平面血管造影射血分数的关系。排除二尖瓣狭窄和主动脉瓣关闭不全（影响前叶运动的疾病）的15例患者后，发现两者之间存在强负相关（r=-0.87，P <0.001）。二尖瓣间隔分离和射血分数在其余110。将60例冠心病患者单独考虑时，相关性仍然很高（r=-0.86，P <0.001）。与其他超声心动图心室功能指标相比，E点室间隔分离与血管造影射血分数的相关性更密切，在区分射血分数正常和低射血分数患者方面更有用。该指数似乎是特别有用的，因为它的简单的测定和其在冠状动脉疾病患者的可靠性。我们假设二尖瓣间隔分离是由多种血流动力学和几何因素决定的，但在大多数患者中反映了舒张早期心室充盈量和速率与心室大小之间的相互作用。
An echocardiographic measurement of the minimal separation between the anterior mitral valve leaflet at its E point and the Interventricular septum was evaluated as an index of left ventricular function. Mitral-septal separation was found to be easily measured, reproducible and independent of patient position or heart rate changes of up to 32 beats/min. In a group of 30 normal subjects, E point-septal separation was absent in 25 and minimal (less than 4 mm) in the remaining 5. The relation of this variable to biplane angiographic ejection fraction was examined in 125 patients with a variety of cardiac diseases. After the 15 patients with mitral stenosis and aortic insufficiency (conditions that affect anterior leaflet motion) were excluded, a strong negative correlation (r= −0.87,P<0.001) was found between. mitrai-septal separation and ejection fraction in the remaining 110. The correlation remained high (r= −0.86,P<0.001) when the 60 patients with coronary artery disease were considered separately. When compared with other echographic indexes of ventricular function, E point-septal separation correlated more closely with angiographic ejection fraction and was more useful in discriminating between patients with normal and those with low ejection fraction. This index appears to be especially useful because of the simplicity of its determination and its reliability in patients with coronary artery disease. We hypothesize that mitral-septal separation is determined by multiple hemodynamic and geometric factors but in most patients reflects an interplay between the amount and rate of early diastolic ventricular filling and ventricular size.