Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations.
Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations.
复制标题
拉希德大鼠肉瘤病毒癌基因的核苷酸序列：新突变。
DOI：
10.1126/science.6344220
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Heidecker,G
中科院分区：
文献类型：
--
作者：
Rasheed,S;Norman,GL;Heidecker,G
测定了大鼠肉瘤病毒拉希德株致癌基因的核苷酸序列。致癌基因（Ra-v-ras）编码29,000道尔顿（p29）转化蛋白。该蛋白与哈维小鼠肉瘤病毒免疫相关的21,000道尔顿蛋白（p21）在其氨基端和羧基端有额外的突变不同。虽然这些变化的功能意义尚不清楚，但它们似乎只发生在大鼠肉瘤病毒中。
The nucleotide sequence of the oncogene of the Rasheed strain of rat sarcoma virus was determined. The oncogene (Ra-v-ras) encodes a 29,000-dalton (p29) transforming protein. This protein is distinct from the immunologically related 21,000-dalton protein (p21) of the Harvey murine sarcoma virus in its amino terminus and in having additional mutations in its carboxyl terminus. Although the functional significance of these changes is unknown, they appear to occur only in rat sarcoma virus.