The induction of anterior chamber-associated immune deviation.
The induction of anterior chamber-associated immune deviation.
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DOI：
10.1159/000099251
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Niederkorn, Jerry Y
中科院分区：
文献类型：
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作者：
Niederkorn, Jerry Y
眼部免疫豁免的证据在大约130年前就被注意到了。在过去的30年里，眼免疫豁免的研究出现了爆炸式的增长。导致眼部免疫豁免的主要机制之一是当抗原被引入眼睛的前房（AC）时引发的独特形式的免疫偏离-一种称为AC相关免疫偏离（ACAID）的现象。ACAID包含一系列细胞相互作用和至少四个不同的器官系统：眼睛、胸腺、脾脏和交感神经系统。至少有四种不同的细胞群相互作用，产生CD 8 + T调节细胞，抑制Th 1和Th 2介导的炎症。F4/80+抗原呈递细胞、CD 4 + T调节细胞、NK 1.1 + T细胞、γ δ T细胞、B细胞和CD 8 + T细胞之间的相互作用仍有待充分阐明。眼部免疫豁免最初被认为是一种简单的解剖异常，已演变为最复杂和最有趣的免疫调节形式之一。
Evidence of ocular immune privilege was noted almost 130 years ago. The past 30 years have witnessed an explosion in research on ocular immune privilege. One of the primary mechanisms that contribute to ocular immune privilege is the unique form of immune deviation that is invoked when antigens are introduced into the anterior chamber (AC) of the eye - a phenomenon termed AC-associated immune deviation (ACAID). ACAID embodies a constellation of cellular interactions and at least four different organ systems: eye, thymus, spleen, and sympathetic nervous system. At least four different cell populations interact to generate CD8+ T regulatory cells that suppress both Th1- and Th2-mediated inflammation. The interactions that occur between F4/80+ antigen-presenting cells, CD4+ T regulatory cells, NK1.1+ T cells, gammadelta T cells, B cells, and CD8+ T cells remain to be fully elucidated. Ocular immune privilege was originally perceived as a simple anatomic anomaly that has evolved to be one of the most sophisticated and intriguing forms of immune regulation.