Molecular species composition of plasma phosphatidylcholine in human pregnancy.
Molecular species composition of plasma phosphatidylcholine in human pregnancy.
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人类妊娠血浆磷脂酰胆碱的分子种类组成。
DOI：
10.1159/000423561
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发表时间：
1994
影响因子：
--
通讯作者：
Monique D.M. Al
中科院分区：
文献类型：
--
作者：
A. Postle;Graham C. Burdge;Monique D.M. Al
结果总血浆PC浓度在妊娠期间稳步上升，从16周时的2.16±0.40 mM上升到分娩时的2.93±0.57 mM (p< 0.001)，产后下降（表1）。胎儿脐带血浆PC浓度明显降低（1.28±0.39 mM）。所有血浆样品均分离出相同的16种PC分子；母体血浆中超过50%的PC种在sn-2位置含有亚油酸（18:2），而胎儿血浆中含有20:4（31%）的亚油酸。六种含不饱和脂肪酸的PC在母体血浆中的浓度见表1。血浆PC浓度的增加完全是由于含有sn-1 16: 0的物种的选择性增加；含有sn-1 18:0的物种的浓度在整个妊娠期间没有改变。
ResultsTotal plasma PC concentration increased steadily throughout pregnancy, from a value of 2.16±0.40 mM at 16 weeks to a maximum of 2.93±0.57 mM at delivery (p< 0.001), and declined postnatally (table 1). PC concentration in fetal cord plasma was considerably lower (1.28±0.39 mM). The same 16 molecular species of PC were resolved in all plasma samples; over 50% of PC species in maternal plasma contained linoleate (18: 2) at the sn-2 position, while fetal plasma was enriched in species containing 20: 4 (31%). Concentrations in maternal plasma of the six PC species containing unsaturated fatty acid are given in table 1. The increase in plasma PC concentration was accounted for totally by a selective increase in species containing sn-1 16: 0; concentrations of species containing sn-1 18: 0 did not alter throughout gesta-tion.