The pathology of multiple sclerosis: evidence for heterogeneity.
The pathology of multiple sclerosis: evidence for heterogeneity.
复制标题
DOI：
--
复制
发表时间：
2006
影响因子：
--
通讯作者：
Y. Morales;J. Parisi;C. Lucchinetti
中科院分区：
文献类型：
--
作者：
Y. Morales;J. Parisi;C. Lucchinetti
特发性炎症性脱髓鞘疾病（IIDD）由广泛的疾病组成，其临床病程、区域分布和病理学各不相同。尽管这些脱髓鞘疾病的病理学表现出广泛的个体间异质性，但个体患者内存在显著的同质性。IIDDs的不同潜在病理学与各种临床、副临床和放射学结果之间的关系尚不清楚。寻找侵入性较小的临床或临床旁替代标记物，准确可靠地预测IIDD家族中潜在的不同病理，可能会指导未来更好地靶向特定致病机制的治疗。
The idiopathic inflammatory demyelinating diseases (IIDDs) consist of a broad spectrum of disorders that vary in their clinical course, regional distribution, and pathology. Though pathology of these demyelinating disorders demonstrates extensive interindividual heterogeneity, there is notable homogeneity within individual patients. The relation between the diverse underlying pathology of IIDDs and the various clinical, paraclinical, and radiological findings is unclear. Finding less-invasive clinical or paraclinical surrogate markers, which accurately and reliably predict the underlying distinct pathologies within the family of IIDDs, can potentially guide future therapies that better target specific pathogenic mechanisms.