Metabolic Functions of the Lung, Disorders and Associated Pathologies.
Metabolic Functions of the Lung, Disorders and Associated Pathologies.
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DOI：
10.14740/jocmr2668w
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Arce I
中科院分区：
文献类型：
--
作者：
Alvarado A;Arce I
肺的主要功能是大约4亿年前的气体，地球的大气在气相中获得了足够的氧气，用于从海中出现的动物。在用作气体交换器官以补充g的墙壁上，随着动物习惯于唯一的陆地生命将隔室的隔室提供了o2摄取和二氧化碳进化所需的巨大气管表面，并根据代谢需求和其他需求而开发了呼吸控制系统，以调节呼吸。维持体内平衡的专业功能，我们称之为肺的非呼吸功能，并且经常被认为几乎没有或没有与替代气体的联系。出现疾病，简洁地讨论了它们，强调了它们如何影响肺的最重要功能：外部呼吸。
The primary function of the lungs is gas exchange. Approximately 400 million years ago, the Earth’s atmosphere gained enough oxygen in the gas phase for the animals that emerged from the sea to breathe air. The first lungs were merely primitive air sacs with a few vessels in the walls that served as accessory organs of gas exchange to supplement the gills. Eons later, as animals grew accustomed to a solely terrestrial life, the lungs became highly compartmentalized to provide the vast air-blood surface necessary for O2 uptake and CO2 elimination, and a respiratory control system was developed to regulate breathing in accordance with metabolic demands and other needs. With the evolution and phylogenetic development, lungs were taking a variety of other specialized functions to maintain homeostasis, which we will call the non-respiratory functions of the lung and that often, and by mistake, are believed to have little or no connection with the replacement gas. In this review, we focus on the metabolic functions of the lung, perhaps the least known, and mainly, in the lipid metabolism and blood-adult lung vascular endothelium interaction. When these functions are altered, respiratory disorders or diseases appear, which are discussed concisely, emphasizing how they impact the most important function of the lungs: external respiration.