Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury
Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury
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DOI：
10.1080/02699050500488207
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发表时间：
2006-06-01
期刊：
影响因子：
1.9
通讯作者：
Stigbrand, Torgney
中科院分区：
文献类型：
--
作者：
Bazarian, Jeffrey J.;Zemlan, Frank P.;Stigbrand, Torgney
主要目标：确定血清S-100 B和C-tau水平与轻度创伤性脑损伤后长期预后的关系（轻度TBI）。研究设计：对急诊科就诊的35名轻度TBI受试者进行前瞻性研究。方法和程序：6小时血清S-100 B和C-tau水平与3个月Rivermead脑震荡后问卷（RPCQ）评分和脑震荡后综合征（PCS）的比较主要结果与结论：RPCQ评分与血清标志物水平呈弱线性相关（S-100 B：r = 0.071，C-tau：r = -0.21）。标记物水平与3个月PCS之间无统计学显著相关性（S-100 B：AUC = 0.589，95% CI）。038，0.80; C-tau：AUC = 0.634，95%CI 0.43，0.84）。结论：血清S-100 B和C-tau水平对轻度TBI后3个月预后的预测价值较低。
Primary objective: To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI).Research design: A prospective study of 35 mild TBI subjects presenting to the emergency department.Methods and procedures: Six hour serum S-100B and C-tau levels compared to 3-month Rivermead Post Concussion Questionnaire (RPCQ) scores and post- concussive syndrome (PCS).Main outcomes and results: The linear correlation between marker levels and RPCQ scores was weak (S-100B: r = 0.071, C-tau: r = -0.21). There was no statistically significant correlation between marker levels and 3-month PCS (S-100B: AUC = 0.589, 95% CI. 038, 0.80; C-tau: AUC = 0.634, 95% CI 0.43, 0.84). The sensitivity of these markers ranged from 43.8-56.3% and the specificity from 35.7-71.4%.Conclusions: Initial serum S-100B and C-tau levels appear to be poor predictors of 3-month outcome after mild TBI.