Neural isolation of the entire canine stomach in vivo: effects on motility.
Neural isolation of the entire canine stomach in vivo: effects on motility.
复制标题
体内整个犬胃的神经隔离：对运动的影响。
DOI：
10.1152/ajpgi.1989.257.1.g30
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Tanaka,M
中科院分区：
文献类型：
--
作者：
VanLierRibbink,JA;Sarr,MG;Tanaka,M
本研究旨在确定切断整个胃的所有外在和肠神经连续性对胃和小肠运动模式的影响。五只狗进行原位自体移植的胃，以实现在体内的模型，“神经隔离”的胃。植入测压导管和servial电极。一个周期性的运动模式发生在禁食，并密切协调的时间与移行运动复合波（MMC）在小肠。周期性胃运动活动的周期与小肠中MMC的周期无差异[121 +/- 8 vs 124 +/- 10（平均值+/- SE）min，P = 0.4]，但两者的周期均大于对照犬（93 +/- 5 min，P <0.05）。在神经隔离犬中，胃速占空腹肌电活动的36 +/- 13%，而在对照犬中不到1%。血浆胃动素浓度最大的III期样胃运动活动，外源性胃动素诱导过早的III期样活动在胃和小肠。喂食可使胃的周期性运动消失，血浆胃动素浓度降低。这些数据表明，激素的因素，而不是外在或内在的神经连续性的胃，可能会控制启动一个周期性的消化间期胃运动模式和它的时间协调与运动模式在小肠。
This study was designed to determine the effects of transection of all extrinsic and enteric neural continuity to the entire stomach on motility patterns of the stomach and small intestine. Five dogs were subjected to a model of orthotopic autotransplantation of the stomach to achieve an in vivo, "neurally isolated" stomach. Manometric catheters and serosal electrodes were implanted. A cyclic motor pattern occurred during fasting and was closely coordinated temporally with the migrating motor complex (MMC) in the small bowel. The period of the cyclic gastric motor activity did not differ from the period of the MMC in the small intestine [121 +/- 8 vs 124 +/- 10 (means +/- SE) min, P = 0.4], but the periods of both were greater than in control dogs (93 +/- 5 min, P less than 0.05). Tachygastria accounted for 36 +/- 13% of fasting myoelectric activity in the neurally isolated dogs and for less than 1% in control dogs. Plasma concentration of motilin was greatest during the phase III-like gastric motor activity; exogenous motilin induced premature phase III-like activity in the stomach and small intestine. Feeding abolished the cyclic motor activity in the stomach and decreased plasma motilin concentration. These data suggest that hormonal factors, and not extrinsic or intrinsic neural continuity to the stomach, may control both the initiation of a cyclic interdigestive gastric motor pattern and its temporal coordination with motor patterns in the small intestine.