ACTIVITY OF SINGLE NEURONS IN HYPOTHALAMIC FEEDING CENTERS - EFFECT OF GLUCOSE
ACTIVITY OF SINGLE NEURONS IN HYPOTHALAMIC FEEDING CENTERS - EFFECT OF GLUCOSE
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DOI：
10.1152/ajplegacy.1964.207.5.1146
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发表时间：
1964-01-01
影响因子：
--
通讯作者：
CHHINA, GS
中科院分区：
文献类型：
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作者：
ANAND, BK;SINGH, B;CHHINA, GS
在手术暴露下丘脑的麻醉犬和采用Flaxedil固定的立体定位方法的猫中记录下丘脑摄食和饱足机制神经元以及相邻下丘脑区域的单位活动。静脉注射葡萄糖或胰岛素，或两者的组合，并观察尖峰活动的变化。对从股动脉和静脉采集的血液样本进行葡萄糖估计。在饥饿的动物中，饱腹中枢神经元的单位活动比摄食中枢神经元的单位活动慢。静脉注射葡萄糖后，饱腹中枢神经元的峰电位频率显著增加，摄食中枢神经元的峰电位频率显著降低，而静脉注射胰岛素后，这些中枢神经元的峰电位活动表现出相反的反应模式。其他下丘脑和皮质神经元未见明显变化。饱腹中枢神经元的活动与血糖水平本身没有显著相关性，但单位活动与A-V葡萄糖差之间存在较好的相关性。这表明饱腹中枢是通过体内葡萄糖利用增加而激活的。
Unit activity from neurons of hypothalamic feeding and satiety mechanisms, and from adjacent hypothalamic regions was recorded in anesthetized dogs with surgically exposed hypothalamus, and in Flaxedil-immobilized cats in which a stereotaxic approach was made. Intravenous glucose or insulin, or combinations of both, were given and the changes in spike activity observed. Glucose estimations were done on blood samples taken from femoral artery and vein. In starved animals the unit activity in satiety center neurons was slower than that obtained from feeding center neurons. Frequency of spikes recorded from satiety center neurons increased and that of feeding center neurons decreased significantly after glucose was given intravenously, while spike activity from these centers showed a reverse pattern of response after intravenous insulin. No significant changes were observed from other hypothalamic and cortical neurons. Activity of neurons of the satiety center did not show a significant correlation with blood glucose level per se, but a better correlation was found between unit activity and the A-V glucose difference. It is suggested that the satiety center is activated by increased glucose utilization in the body.