Ag(I)-Catalyzed Three-Component Reaction of 2-Alkynylbenzaldehydes, Amines, and Diazo Compounds.
Ag(I)-Catalyzed Three-Component Reaction of 2-Alkynylbenzaldehydes, Amines, and Diazo Compounds.
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DOI：
10.1021/acs.orglett.5b02159
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发表时间：
2015-08
期刊：
影响因子：
5.2
通讯作者：
Tiebo Xiao;Pai Peng;Yang Xie;Zhao-yang Wang;Lei Zhou
中科院分区：
文献类型：
--
作者：
Tiebo Xiao;Pai Peng;Yang Xie;Zhao-yang Wang;Lei Zhou
重氮化合物已被用作银催化的胺和2-炔基苯甲醛的三组分反应中的亲核试剂。采用亚胺炔环化/亲核加成/1，2-芳基迁移级联反应，一锅法合成了3-苯并氮杂卓类化合物。此外，这种Ag（I）介导的反应还提供了在稍微修改的条件下制备含重氮基的二氢异喹啉的实用途径。
Diazo compounds have been employed as the nucleophile in a silver-catalyzed three-component reaction with amines and 2-alkynylbenzaldehydes. Various 3-benzazepines were prepared in a one-pot manner based on a cascade imine--yne cyclization/nucleophilic addition/1,2-aryl migration process. Moreover, this Ag(I)-mediated reaction also provides a practical route to diazo-containing dihydroisoquinolines under slightly modified conditions.