Suppression of cell-mediated tumour immunity by Corynebacterium parvum
Suppression of cell-mediated tumour immunity by Corynebacterium parvum
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DOI：
10.1038/257396a0
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发表时间：
1975-10
期刊：
影响因子：
64.8
通讯作者：
H. Kirchner;M. Glaser;R. Herberman
中科院分区：
文献类型：
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作者：
H. Kirchner;M. Glaser;R. Herberman
免疫佐剂在肿瘤治疗中的使用主要基于这样的概念：通过非特异性刺激免疫系统可以提高针对肿瘤相关抗原的特异性免疫水平（综述参见参考文献1）。在这些佐剂中，小棒状杆菌备受关注，因为它是小鼠网状内皮系统最强大的刺激剂之一，并且能有效抑制多种动物肿瘤系统的肿瘤生长（例如，参见参考文献3-6）。 C. 其机制parvum 干扰肿瘤生长的情况尚未确定，C 的肿瘤保护作用也尚未确定。 parvum 在所有研究的系统中并不完全一致。 C.免疫抑制作用parvum也已被证明。在小鼠中，注射 C 后，对有丝分裂原和同种异体抗原的体外淋巴增殖反应被抑制。微小的。然而，通过这些 T 淋巴细胞一般测试测得的缺陷是否也可能代表细胞介导的针对肿瘤细胞的免疫功能低下，仍有待确定。
THE use of immunoadjuvants in tumour therapy is based largely on the concept that an increased level of specific immunity against tumour-associated antigens may be achieved by nonspecific stimulation of the immune system (for review see ref. 1). Among these adjuvants,Corynebacterium parvumhas received much attention since it represents one of the most powerful stimulants of the reticuloendothelial system in mice2, and is effective in inhibiting tumour growth in several animal tumour systems (for example, see refs 3–6). The mechanisms by whichC. parvuminterferes with tumour growth have not been established and the tumour protective effect ofC. parvumhas not been entirely consistent in all systems studied. An immunosuppressive effect ofC. parvumhas been demonstrated too. In mice, thein vitrolymphoproliferative responses to mitogens and to alloantigens were depressed after injection ofC. parvum. It remains to be determined, however, whether a defect measured by these general tests of T lymphocytes may also represent an indication of depressed cell-mediated immunity against tumour cells.