A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function
A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function
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DOI：
10.1016/j.neuron.2005.10.029
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发表时间：
2005-12-22
期刊：
影响因子：
16.2
通讯作者：
Vogt, KE
中科院分区：
文献类型：
--
作者：
Marowsky, A;Yanagawa, Y;Vogt, KE
杏仁核通过局部GABA能中间神经元的激活受到皮质的抑制控制。由于多巴胺的释放，这种抑制在情绪高涨的时候会大大减弱。然而，多巴胺兴奋大多数杏仁核中间神经元，这表明这个多巴胺能门可能是由未知的中间神经元亚群介导的。我们假设这个门是由囊旁间质细胞介导的，这是一个中间神经元的子集，由皮质和中脑边缘的多巴胺能传入神经支配。使用在GABA能中间神经元中表达GFP的转基因小鼠，我们发现囊旁细胞形成了围绕杏仁核基底外侧复合体的网络。我们发现，它们对基底外侧核和中央杏仁核具有前馈抑制作用。多巴胺通过D1受体使囊旁细胞超极化，并显著抑制其兴奋性，导致基底外侧核和中央核的去抑制。多巴胺对包囊旁系统的抑制为应激或其他高多巴胺能状态下观察到的情感行为增加提供了令人信服的神经机制。
The amygdala is under inhibitory control from the cortex through the activation of local GABAergic interneurons. This inhibition is greatly diminished during heightened emotional states due to dopamine release. However, dopamine excites most amygdala interneurons, suggesting that this dopaminergic gate may be mediated by an unknown subpopulation of interneurons. We hypothesized that this gate is mediated by paracapsular intercalated cells, a subset of interneurons that are innervated by both cortical and mesolimbic dopaminergic afferents. Using transgenic mice that express GFP in GABAergic interneurons, we show that paracapsular cells form a network surrounding the basolateral complex of the amygdala. We found that they provide feedforward inhibition into the basolateral and the central amygdala. Dopamine hyperpolarized paracapsular cells through D1 receptors and substantially suppressed their excitability, resulting in a disinhibition of the basolateral and central nuclei. Suppression of the paracapsular system by dopamine provides a compelling neural mechanism for the increased affective behavior observed during stress or other hyperdopaminergic states.